CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014956
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Caprin-2 
Protein Synonyms/Alias
 C1q domain-containing protein 1; Cytoplasmic activation/proliferation-associated protein 2; Gastric cancer multidrug resistance-associated protein; Protein EEG-1; RNA granule protein 140 
Gene Name
 CAPRIN2 
Gene Synonyms/Alias
 C1QDC1; EEG1; KIAA1873; RNG140 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
138HKIRNIEKKKLKLEDacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons. Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation. May be involved in apoptosis. 
Sequence Annotation
 DOMAIN 993 1127 C1q.  
Keyword
 Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Differentiation; Growth regulation; Mitochondrion; Polymorphism; Protein synthesis inhibitor; Reference proteome; RNA-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1127 AA 
Protein Sequence
MEVQVSQASL GFELTSVEKS LREWSRLSRE VIAWLCPSSP NFILNFPPPP SASSVSMVQL 60
FSSPFGYQSP SGHSEEEREG NMKSAKPQVN HSQHGESQRA LSPLQSTLSS AASPSQAYET 120
YIENGLICLK HKIRNIEKKK LKLEDYKDRL KSGEHLNPDQ LEAVEKYEEV LHNLEFAKEL 180
QKTFSGLSLD LLKAQKKAQR REHMLKLEAE KKKLRTILQV QYVLQNLTQE HVQKDFKGGL 240
NGAVYLPSKE LDYLIKFSKL TCPERNESLS VEDQMEQSSL YFWDLLEGSE KAVVGTTYKH 300
LKDLLSKLLN SGYFESIPVP KNAKEKEVPL EEEMLIQSEK KTQLSKTESV KESESLMEFA 360
QPEIQPQEFL NRRYMTEVDY SNKQGEEQPW EADYARKPNL PKRWDMLTEP DGQEKKQESF 420
KSWEASGKHQ EVSKPAVSLE QRKQDTSKLR STLPEEQKKQ EISKSKPSPS QWKQDTPKSK 480
AGYVQEEQKK QETPKLWPVQ LQKEQDPKKQ TPKSWTPSMQ SEQNTTKSWT TPMCEEQDSK 540
QPETPKSWEN NVESQKHSLT SQSQISPKSW GVATASLIPN DQLLPRKLNT EPKDVPKPVH 600
QPVGSSSTLP KDPVLRKEKL QDLMTQIQGT CNFMQESVLD FDKPSSAIPT SQPPSATPGS 660
PVASKEQNLS SQSDFLQEPL QATSSPVTCS SNACLVTTDQ ASSGSETEFM TSETPEAAIP 720
PGKQPSSLAS PNPPMAKGSE QGFQSPPASS SSVTINTAPF QAMQTVFNVN APLPPRKEQE 780
IKESPYSPGY NQSFTTASTQ TPPQCQLPSI HVEQTVHSQE TAANYHPDGT IQVSNGSLAF 840
YPAQTNVFPR PTQPFVNSRG SVRGCTRGGR LITNSYRSPG GYKGFDTYRG LPSISNGNYS 900
QLQFQAREYS GAPYSQRDNF QQCYKRGGTS GGPRANSRAG WSDSSQVSSP ERDNETFNSG 960
DSGQGDSRSM TPVDVPVTNP AATILPVHVY PLPQQMRVAF SAARTSNLAP GTLDQPIVFD 1020
LLLNNLGETF DLQLGRFNCP VNGTYVFIFH MLKLAVNVPL YVNLMKNEEV LVSAYANDGA 1080
PDHETASNHA ILQLFQGDQI WLRLHRGAIY GSSWKYSTFS GYLLYQD 1127 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:UniProtKB.
 GO:0043235; C:receptor complex; IDA:BHF-UCL.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0030308; P:negative regulation of cell growth; IDA:UniProtKB.
 GO:0017148; P:negative regulation of translation; IEA:UniProtKB-KW.
 GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway; IDA:BHF-UCL.
 GO:0050775; P:positive regulation of dendrite morphogenesis; ISS:UniProtKB.
 GO:0061003; P:positive regulation of dendritic spine morphogenesis; ISS:UniProtKB.
 GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IDA:BHF-UCL.
 GO:0032092; P:positive regulation of protein binding; IDA:BHF-UCL.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL. 
Interpro
 IPR001073; C1q.
 IPR022070; Caprin-1_C.
 IPR008983; Tumour_necrosis_fac-like_dom. 
Pfam
 PF00386; C1q
 PF12287; Caprin-1_C 
SMART
 SM00110; C1Q 
PROSITE
 PS50871; C1Q 
PRINTS
 PR00007; COMPLEMNTC1Q.