CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008129
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Natural resistance-associated macrophage protein 2 
Protein Synonyms/Alias
 NRAMP 2; Divalent cation transporter 1; Divalent metal transporter 1; DMT-1 
Gene Name
 Slc11a2 
Gene Synonyms/Alias
 Dct1; Dmt1; Nramp2 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
578GRSVSISKVLLSEDTubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Important in metal transport, in particular iron. Involved in apical iron uptake into duodenal enterocytes. Involved in iron transport from acidified endosomes into the cytoplasm of erythroid precursor cells. May play an important role in hepatic iron accumulation and tissue iron distribution. 
Sequence Annotation
 MOD_RES 21 21 Phosphoserine.
 MOD_RES 564 564 Phosphoserine.
 MOD_RES 567 567 Phosphoserine.
 CARBOHYD 336 336 N-linked (GlcNAc...) (Potential).
 CARBOHYD 349 349 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Complete proteome; Disease mutation; Endosome; Glycoprotein; Ion transport; Iron; Iron transport; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix; Transport; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 568 AA 
Protein Sequence
MGKKQPRAAA AAPNCELKSY SKSTDPQVST MVLDPKEKMP DDGASGDHGD SASLGAINPA 60
YSNSSLPHST GDSEEPFTTY FDEKIPIPEE EYSCFSFRKL WAFTGPGFLM SIAYLDPGNI 120
ESDLQSGAVA GFKLLWVLLL ATIVGLLLQR LAARLGVVTG LHLAEVCHRQ YPKVPRIILW 180
LMVELAIIGS DMQEVIGSAI AINLLSAGRV PLWGGVLITI ADTFVFLFLD KYGLRKLEAF 240
FGFLITIMAL TFGYEYITVK PSQSQVLRGM FVPSCPGCRT PQVEQAVGIV GAVIMPHNMY 300
LHSALVKSRQ VNRANKQEVR EANKYFFIES CIALFVSFII NVFVVSVFAE AFFEKTNKQV 360
VEVCKNNSSP HADLFPSDNS TLAVDIYKGG VVLGCYFGPA ALYIWAVGIL AAGQSSTMTG 420
TYSGQFVMEG FLNLKWSRFA RVILTRSIAI IPTLLVAVFQ DVEHLTGMND FLNVLQSLQL 480
PFALIPILTF TSLRPVMSEF SNGIGWRIAG GILVLIVCSI NMYFVVVYVQ ELGHVALYVV 540
AAVVSVAYLT FVFYLGWQCL IALGLSFLDC GRSVSISKVL LSEDTSGGNI K 591 
Gene Ontology
 GO:0016324; C:apical plasma membrane; IEA:Compara.
 GO:0045178; C:basal part of cell; IEA:Compara.
 GO:0005903; C:brush border; IDA:MGI.
 GO:0009986; C:cell surface; IDA:MGI.
 GO:0031410; C:cytoplasmic vesicle; IEA:Compara.
 GO:0005769; C:early endosome; IDA:MGI.
 GO:0012505; C:endomembrane system; IDA:MGI.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005887; C:integral to plasma membrane; IDA:MGI.
 GO:0031902; C:late endosome membrane; IEA:Compara.
 GO:0005765; C:lysosomal membrane; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0070826; C:paraferritin complex; IEA:Compara.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0055037; C:recycling endosome; IDA:MGI.
 GO:0005802; C:trans-Golgi network; IEA:Compara.
 GO:0015086; F:cadmium ion transmembrane transporter activity; IEA:Compara.
 GO:0015087; F:cobalt ion transmembrane transporter activity; IDA:MGI.
 GO:0005375; F:copper ion transmembrane transporter activity; IEA:Compara.
 GO:0015093; F:ferrous iron transmembrane transporter activity; IDA:MGI.
 GO:0015078; F:hydrogen ion transmembrane transporter activity; IDA:MGI.
 GO:0015094; F:lead ion transmembrane transporter activity; IEA:Compara.
 GO:0005384; F:manganese ion transmembrane transporter activity; IEA:Compara.
 GO:0015099; F:nickel cation transmembrane transporter activity; IEA:Compara.
 GO:0015295; F:solute:hydrogen symporter activity; IEA:Compara.
 GO:0015100; F:vanadium ion transmembrane transporter activity; IEA:Compara.
 GO:0005385; F:zinc ion transmembrane transporter activity; IEA:Compara.
 GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Compara.
 GO:0034599; P:cellular response to oxidative stress; IEA:Compara.
 GO:0006824; P:cobalt ion transport; IEA:Compara.
 GO:0048813; P:dendrite morphogenesis; IMP:MGI.
 GO:0003032; P:detection of oxygen; IEA:Compara.
 GO:0048821; P:erythrocyte development; IMP:MGI.
 GO:0070627; P:ferrous iron import; IDA:MGI.
 GO:0015684; P:ferrous iron transport; IEA:Compara.
 GO:0006783; P:heme biosynthetic process; IMP:MGI.
 GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
 GO:0007611; P:learning or memory; IMP:MGI.
 GO:0060586; P:multicellular organismal iron ion homeostasis; IMP:MGI.
 GO:0015992; P:proton transport; IEA:GOC.
 GO:0001666; P:response to hypoxia; IEA:Compara.
 GO:0010039; P:response to iron ion; IEA:Compara. 
Interpro
 IPR001046; NRAMP-like. 
Pfam
 PF01566; Nramp 
SMART
  
PROSITE
  
PRINTS
 PR00447; NATRESASSCMP.