| Tag | Content |
|---|
| CPLM ID | CPLM-018634 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Synaptotagmin-12 |
Protein Synonyms/Alias | Synaptotagmin XII; SytXII |
Gene Name | Syt12 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 65 | DYRYLQQKYGEAYVE | ubiquitination | [1] | | 74 | GEAYVEAKLKRVPPW | ubiquitination | [1] | | 233 | DPTALEEKSLRFSVF | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis (By similarity). |
Sequence Annotation | DOMAIN 168 272 C2 1.
DOMAIN 285 388 C2 2. |
Keyword | Cell junction; Complete proteome; Cytoplasmic vesicle; Membrane; Reference proteome; Repeat; Synapse; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 421 AA |
Protein Sequence | MAVDVTEYHL SVIKSPPGWE VGVYAAGALA LLGIAAVSLW KLWTSGSFPS PSPFPNYDYR 60
YLQQKYGEAY VEAKLKRVPP WNDQRTTTRG PPSRKGSLSI EDTFESISEL GPLELMGREL 120
DLAPYGTLRK SQSADSLNSI SSVSNTFGQD FTLGQVEVSM DYDGASHTLH VAVLQGKDLL 180
EREEATFESC FMRVSLLPDE QIVGISRIQR NAYSIFFDEK FSVPLDPTAL EEKSLRFSVF 240
GIDEDERNVS TGVVELKLSV LDLPLQPFSG WLYLQDQNKA ADAVGEILLS LSYLPTAERL 300
TVVVVKAKNL IWTNEKSTAD PFVKVYLLQD GRKMSKKKTA VKRDDPNPVF NEAMIFSVPA 360
IVLQDLSLRV TVAESSSDGR GDNVGHVIIG PGVSGMGTTH WNQMLATLRR PVSMWHPVRR 420
N 421 |
Gene Ontology | GO:0030054; C:cell junction; IEA:UniProtKB-KW. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell. GO:0005215; F:transporter activity; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |