CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005508
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Phosphatidylinositol 3-kinase regulatory subunit alpha 
Protein Synonyms/Alias
 PI3-kinase regulatory subunit alpha; PI3K regulatory subunit alpha; PtdIns-3-kinase regulatory subunit alpha; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; PI3-kinase subunit p85-alpha; PtdIns-3-kinase regulatory subunit p85-alpha 
Gene Name
 Pik3r1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
382GGNNKLIKIFHRDGKubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (By similarity). 
Sequence Annotation
 DOMAIN 3 79 SH3.
 DOMAIN 113 301 Rho-GAP.
 DOMAIN 333 428 SH2 1.
 DOMAIN 624 718 SH2 2.
 MOD_RES 467 467 Phosphotyrosine.
 MOD_RES 580 580 Phosphotyrosine (By similarity).
 MOD_RES 607 607 Phosphotyrosine.
 MOD_RES 608 608 Phosphoserine (By similarity).  
Keyword
 Complete proteome; Direct protein sequencing; Phosphoprotein; Reference proteome; Repeat; SH2 domain; SH3 domain; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 724 AA 
Protein Sequence
MSAEGYQYRA LYDYKKEREE DIDLHLGDIL TVNKGSLVAL GFSDGQEARP EDIGWLNGYN 60
ETTGERGDFP GTYVEYIGRK RISPPTPKPR PPRPLPVAPG SSKTEADTEQ QALPLPDLAE 120
QFAPPDVAPP LLIKLLEAIE KKGLECSTLY RTQSSSNPAE LRQLLDCDAA SVDLEMIDVH 180
VLADAFKRYL ADLPNPVIPV AVYNEMMSLA QELQSPEDCI QLLKKLIRLP NIPHQCWLTL 240
QYLLKHFFKL SQASSKNLLN ARVLSEIFSP VLFRFPAASS DNTEHLIKAI EILISTEWNE 300
RQPAPALPPK PPKPTTVANN SMNNNMSLQD AEWYWGDISR EEVNEKLRDT ADGTFLVRDA 360
STKMHGDYTL TLRKGGNNKL IKIFHRDGKY GFSDPLTFNS VVELINHYRN ESLAQYNPKL 420
DVKLLYPVSK YQQDQVVKED NIEAVGKKLH EYNTQFQEKS REYDRLYEEY TRTSQEIQMK 480
RTAIEAFNET IKIFEEQCQT QERYSKEYIE KFKREGNEKE IQRIMHNHDK LKSRISEIID 540
SRRRLEEDLK KQAAEYREID KRMNSIKPDL IQLRKTRDQY LMWLTQKGVR QKKLNEWLGN 600
ENTEDQYSLV EDDEDLPHHD EKTWNVGSSN RNKAENLLRG KRDGTFLVRE SSKQGCYACS 660
VVVDGEVKHC VINKTATGYG FAEPYNLYSS LKELVLHYQH TSLVQHNDSL NVTLAYPVYA 720
QQRR 724 
Gene Ontology
 GO:0005943; C:1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex; ISS:UniProtKB.
 GO:0016020; C:membrane; IDA:UniProtKB.
 GO:0016303; F:1-phosphatidylinositol-3-kinase activity; TAS:MGI.
 GO:0043125; F:ErbB-3 class receptor binding; ISS:UniProtKB.
 GO:0043559; F:insulin binding; IEA:Compara.
 GO:0005158; F:insulin receptor binding; ISS:UniProtKB.
 GO:0005159; F:insulin-like growth factor receptor binding; ISS:UniProtKB.
 GO:0035014; F:phosphatidylinositol 3-kinase regulator activity; ISS:UniProtKB.
 GO:0030183; P:B cell differentiation; IMP:MGI.
 GO:0034644; P:cellular response to UV; IMP:MGI.
 GO:0060396; P:growth hormone receptor signaling pathway; IEA:Compara.
 GO:0008286; P:insulin receptor signaling pathway; ISS:UniProtKB.
 GO:0048009; P:insulin-like growth factor receptor signaling pathway; ISS:UniProtKB.
 GO:0043066; P:negative regulation of apoptotic process; IDA:MGI.
 GO:0001953; P:negative regulation of cell-matrix adhesion; IGI:MGI.
 GO:0045671; P:negative regulation of osteoclast differentiation; IGI:MGI.
 GO:0051531; P:NFAT protein import into nucleus; IMP:MGI.
 GO:0014065; P:phosphatidylinositol 3-kinase cascade; IEA:Compara.
 GO:0043065; P:positive regulation of apoptotic process; IMP:MGI.
 GO:0030335; P:positive regulation of cell migration; IGI:MGI.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:MGI.
 GO:0006468; P:protein phosphorylation; IDA:MGI. 
Interpro
 IPR001720; PI3kinase_P85.
 IPR008936; Rho_GTPase_activation_prot.
 IPR000198; RhoGAP_dom.
 IPR000980; SH2.
 IPR011511; SH3_2.
 IPR001452; SH3_domain. 
Pfam
 PF00620; RhoGAP
 PF00017; SH2
 PF07653; SH3_2 
SMART
 SM00324; RhoGAP
 SM00252; SH2
 SM00326; SH3 
PROSITE
 PS50238; RHOGAP
 PS50001; SH2
 PS50002; SH3 
PRINTS
 PR00678; PI3KINASEP85.
 PR00401; SH2DOMAIN.