UniProt Accession

 B4DE93_HUMAN; B4DE93 

Genbank Protein ID

 AP003385; AK293522; AK316122 

Genbank Nucleotide ID

 BAG57004.1; BAH14493.1 

Protein Name

 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial 

Protein Synonyms/Alias

 cDNA FLJ57949, highly similar to NADH-ubiquinone oxidoreductase 51 kDa subunit, mitochondrial (EC 1.6.5.3); cDNA, FLJ79021, highly similar to NADH-ubiquinone oxidoreductase 51 kDa subunit, mitochondrial (EC 1.6.5.3) 

Gene Name

 NDUFV1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
25	EGEPGTCKDREILRH	ubiquitination	[1, 2]
36	ILRHDPHKLLEGCLV	ubiquitination	[2]
264	DRSTDIVKAIARLIE	ubiquitination	[2]
274	ARLIEFYKHESCGQC	acetylation	[3]
274	ARLIEFYKHESCGQC	ubiquitination	[2]
293	EGVDWMNKVMARFVR	ubiquitination	[2, 4]

Reference

 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Monoclonal antibody cocktail as an enrichment tool for acetylome analysis.
 Shaw PG, Chaerkady R, Zhang Z, Davidson NE, Pandey A.
 Anal Chem. 2011 May 15;83(10):3623-6. [PMID: 21466224]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome; Ubiquinone. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 363 AA 

Protein Sequence

Gene Ontology

 GO:0005743; C:mitochondrial inner membrane; IEA:Compara.
 GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:InterPro.
 GO:0010181; F:FMN binding; IEA:InterPro.
 GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro. 

Interpro

 IPR001949; NADH-UbQ_OxRdtase_51kDa_CS.
 IPR019575; NADH-UbQ_OxRdtase_Fsu_4Fe4S-bd.
 IPR011538; NADH_UbQ_OxRdtase_51kDa_su.
 IPR019554; Soluble_ligand-bd. 

Pfam

 PF01512; Complex1_51K
 PF10589; NADH_4Fe-4S
 PF10531; SLBB 

SMART

 SM00928; NADH_4Fe-4S 

PROSITE

 PS00644; COMPLEX1_51K_1
 PS00645; COMPLEX1_51K_2 

PRINTS