CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027662
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Thymidylate synthase 
Protein Synonyms/Alias
 Thymidylate synthetase, isoform CRA_a 
Gene Name
 TS 
Gene Synonyms/Alias
 TYMS; hCG_1994842 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
77EFPLLTTKRVFWKGVubiquitination[1]
93EELLWFIKGSTNAKEubiquitination[1]
99IKGSTNAKELSSKGVubiquitination[1]
104NAKELSSKGVKIWDAubiquitination[1]
107ELSSKGVKIWDANGSubiquitination[1]
258VEKIDDFKAEDFQIEubiquitination[1]
274YNPHPTIKMEMAV**ubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 279 AA 
Protein Sequence
MPVAGSELPR RPLPPAAQER DAEPRPPHGE LQYLGQIQHI LRCGVRKDDR TGTGTLSVFG 60
MQARYSLRDE FPLLTTKRVF WKGVLEELLW FIKGSTNAKE LSSKGVKIWD ANGSRDFLDS 120
LGFSTREEGD LGPVYGFQWR HFGAEYRDME SDLPLMALPP CHALCQFYVV NSELSCQLYQ 180
RSGDMGLGVP FNIASYALLT YMIAHITGLK PGDFIHTLGD AHIYLNHIEP LKIQLQREPR 240
PFPKLRILRK VEKIDDFKAE DFQIEGYNPH PTIKMEMAV 279 
Gene Ontology
 GO:0004799; F:thymidylate synthase activity; IEA:InterPro.
 GO:0006231; P:dTMP biosynthetic process; IEA:InterPro. 
Interpro
 IPR023451; Thymidate_synth/dCMP_Mease.
 IPR000398; Thymidylate_synthase. 
Pfam
 PF00303; Thymidylat_synt 
SMART
  
PROSITE
  
PRINTS
 PR00108; THYMDSNTHASE.