CPLM-024557

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-024557

UniProt Accession

SFI1_HUMAN; A8K8P3; A1L373; A1L387; A2A2L2; B1AKL9; B5MDB7; B7Z1V6; B7Z8G3; B7ZBE2; B7ZBE3; O60289; Q2TAN8; Q5W1B5; Q86TK0; Q8N4U8; Q8N8C1; Q8WU14

Genbank Protein ID

AB011114; AK292408; AK293987; AK303362; AL109802; AL096701; AL096768; AL096701; AL096768; AL109802; AL096768; AL096701; AL109802; AL109802; AL096701; AL096768; AL096701; AL096768; AL109802; AL096701; AL096768; AL096701; AL109802; AL096768; AL096701; AL109802; AL096768; AL096701; AL109802; AL109802; AL096701; AL096768; AL109802; AL096701; AL096768; BC021576; BC110814; BC129926; BC129945

Genbank Nucleotide ID

BAA25468.2; BAF85097.1; BAH11642.1; BAH13949.1; CAH70755.2; CAH70755.2; CAH70755.2; CAI12881.1; CAI12881.1; CAI12881.1; CAI23034.2; CAI23034.2; CAI23034.2; CAM13202.2; CAM13202.2; CAM13202.2; CAM14700.1; CAM14700.1; CAM14700.1; CAM14701.1; CAM28334.2; CAM28334.2; CAM28334.2; CAX14857.1; CAX14857.1; CAX14857.1; CAX14858.1; CAX14858.1; CAX14858.1; CAX15240.1; CAX15240.1; CAX15240.1; CAX15241.1; CAX15241.1; CAX15241.1; AAH21576.1; AAI10815.1; AAI29927.1; AAI29946.1

Protein Name

Protein SFI1 homolog

Protein Synonyms/Alias

hSFI1

Gene Name

SFI1

Gene Synonyms/Alias

KIAA0542

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
34	KVDSRYFKDGAVKKP	ubiquitination	[1]
795	LEGLARWKTHHLQCV	ubiquitination	[1]
901	LRFAASMKASRQQLQ	ubiquitination	[1]
1111	QRATPRDKPPVPSSL	ubiquitination	[1]

Reference

[1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]

Functional Description

Plays a role in the dynamic structure of centrosome- associated contractile fibers via its interaction with CETN2.

Sequence Annotation

REPEAT 138 170 HAT 1.
REPEAT 172 201 HAT 2.
REPEAT 270 302 HAT 3.
REPEAT 334 368 HAT 4.
REPEAT 399 431 HAT 5.
REPEAT 1148 1180 HAT 6.
REGION 111 130 Interaction with CETN2.
REGION 475 494 Interaction with CETN2.
REGION 641 660 Interaction with CETN2.

Keyword

3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton; Polymorphism; Reference proteome; Repeat.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

1242 AA

Protein Sequence

MKNLLTEKCI SSHNFHQKVI KQRMEKKVDS RYFKDGAVKK PYSAKTLSNK KSSASFGIRR 60
ELPSTSHLVQ YRGTHTCTRQ GRLRELRIRC VARKFLYLWI RMTFGRVFPS KARFYYEQRL 120
LRKVFEEWKE EWWVFQHEWK LCVRADCHYR YYLYNLMFQT WKTYVRQQQE MRNKYIRAEV 180
HDAKQKMRQA WKSWLIYVVV RRTKLQMQTT ALEFRQRIIL RVWWSTWRQR LGQVRVSRAL 240
HASALKHRAL SLQVQAWSQW REQLLYVQKE KQKVVSAVKH HQHWQKRRFL KAWLEYLQVR 300
RVKRQQNEMA ERFHHVTVLQ IYFCDWQQAW ERRESLYAHH AQVEKLARKM ALRRAFTHWK 360
HYMLLCAEEA AQFEMAEEHH RHSQLYFCFR ALKDNVTHAH LQQIRRNLAH QQHGVTLLHR 420
FWNLWRSQIE QKKERELLPL LHAAWDHYRI ALLCKCIELW LQYTQKRRYK QLLQARADGH 480
FQQRALPAAF HTWNRLWRWR HQENVLSARA TRFHRETLEK QVFSLWRQKM FQHRENRLAE 540
RMAILHAERQ LLYRSWFMWH QQAAARHQEQ EWQTVACAHH RHGRLKKAFC LWRESAQGLR 600
TERTGRVRAA EFHMAQLLRW AWSQWRECLA LRGAERQKLM RADLHHQHSV LHRALQAWVT 660
YQGRVRSILR EVAARESQHN RQLLRGALRR WKENTMARVD EAKKTFQAST HYRRTICSKV 720
LVQWREAVSV QMYYRQQEDC AIWEAQKVLD RGCLRTWFQR WWDCSRRSAQ QRLQLERAVQ 780
HHHRQLLLEG LARWKTHHLQ CVRKRLLHRQ STQLLAQRLS RTCFRQWRQQ LAARRQEQRA 840
TVRALWFWAF SLQAKVWATW LAFVLERRRK KARLQWALQA YQGQLLQEGA TRLLRFAASM 900
KASRQQLQAQ QQVQAAHSLH RAVRRCATLW KQKVLGRGGK PQPLAAIAPS RKVTFEGPLL 960
NRIAAGAGDG TLETKRPQAS RPLGALGRLA AEEPHALELN TAHSARKQPR RPHFLLEPAQ 1020
SQRPQKPQEH GLGMAQPAAP SLTRPFLAEA PTALVPHSPL PGALSSAPGP KQPPTASTGP 1080
ELLLLPLSSF MPCGAAAPAR VSAQRATPRD KPPVPSSLAS VPDPHLLLPG DFSATRAGPG 1140
LSTAGSLDLE AELEEIQQQL LHYQTTKQNL WSCRRQASSL RRWLELNREE PGPEDQEVEQ 1200
QVQKELEQVE MQIQLLAEEL QAQRQPIGAC VARIQALRQA LC 1242

Gene Ontology

GO:0005814; C:centriole; IEA:UniProtKB-SubCell.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0019902; F:phosphatase binding; IDA:UniProtKB.
GO:0000086; P:G2/M transition of mitotic cell cycle; TAS:Reactome.
GO:0010923; P:negative regulation of phosphatase activity; IDA:UniProtKB.

Interpro

Pfam

SMART

PROSITE

PRINTS