CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021863
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 BAG family molecular chaperone regulator 3 
Protein Synonyms/Alias
 BAG-3; Bcl-2-associated athanogene 3; Bcl-2-binding protein Bis 
Gene Name
 Bag3 
Gene Synonyms/Alias
 Bis; MNCb-2243 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
255PQQPVYHKIQGDDWEubiquitination[1]
366KSPPPAEKVEVKVSSacetylation[2]
450AVDSFEGKKTDKKYLubiquitination[1]
455EGKKTDKKYLMIEEYubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
 Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity. 
Sequence Annotation
 DOMAIN 22 56 WW 1.
 DOMAIN 126 157 WW 2.
 DOMAIN 426 503 BAG.
 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 204 204 Phosphoserine (By similarity).
 MOD_RES 280 280 Phosphoserine (By similarity).
 MOD_RES 281 281 Phosphoserine (By similarity).
 MOD_RES 285 285 Phosphoserine (By similarity).
 MOD_RES 291 291 Phosphothreonine (By similarity).
 MOD_RES 297 297 Phosphoserine.
 MOD_RES 382 382 Phosphoserine (By similarity).
 MOD_RES 390 390 Phosphoserine.  
Keyword
 3D-structure; Acetylation; Apoptosis; Chaperone; Complete proteome; Phosphoprotein; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 577 AA 
Protein Sequence
MSAATQSPMM QMASGNGASD RDPLPPGWEI KIDPQTGWPF FVDHNSRTTT WNDPRVPPEG 60
PKDTASSANG PSRDGSRLLP IREGHPIYPQ LRPGYIPIPV LHEGSENRQP HLFHAYSQPG 120
VQRFRTEAAA ATPQRSQSPL RGGMTEAAQT DKQCGQMPAT ATTAAAQPPT AHGPERSQSP 180
AASDCSSSSS SASLPSSGRS SLGSHQLPRG YIPIPVIHEQ NITRPAAQPS FHQAQKTHYP 240
AQQGEYQPQQ PVYHKIQGDD WEPRPLRAAS PFRSPVRGAS SREGSPARSG TPVHCPSPIR 300
VHTVVDRPQP MTHREPPPVT QPENKPESKP GPAGPDLPPG HIPIQVIRRE ADSKPVSQKS 360
PPPAEKVEVK VSSAPIPCPS PSPAPSAVPS PPKNVAAEQK AAPSPAPAEP AAPKSGEAET 420
PPKHPGVLKV EAILEKVQGL EQAVDSFEGK KTDKKYLMIE EYLTKELLAL DSVDPEGRAD 480
VRQARRDGVR KVQTILEKLE QKAIDVPGQV QVYELQPSNL EAEQPLQEIM GAVVADKDKK 540
GPENKDPQTE SQQLEAKAAT PPNPSNPADS AGNLVAP 577 
Gene Ontology
 GO:0005829; C:cytosol; ISO:MGI.
 GO:0043005; C:neuron projection; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0030018; C:Z disc; IDA:MGI.
 GO:0032403; F:protein complex binding; IDA:MGI.
 GO:0007420; P:brain development; IEA:Compara.
 GO:0071260; P:cellular response to mechanical stimulus; IMP:MGI.
 GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IDA:MGI.
 GO:0008625; P:extrinsic apoptotic signaling pathway via death domain receptors; ISO:MGI.
 GO:0010664; P:negative regulation of striated muscle cell apoptotic process; IMP:MGI.
 GO:0050821; P:protein stabilization; IMP:MGI.
 GO:0021510; P:spinal cord development; IEA:Compara. 
Interpro
 IPR003103; BAG_domain.
 IPR001202; WW_dom. 
Pfam
 PF02179; BAG
 PF00397; WW 
SMART
 SM00264; BAG
 SM00456; WW 
PROSITE
 PS51035; BAG
 PS01159; WW_DOMAIN_1
 PS50020; WW_DOMAIN_2 
PRINTS