CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036801
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Retinol dehydrogenase 10 
Protein Synonyms/Alias
  
Gene Name
 RDH10 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
154YRFLGADKCMYPFIAubiquitination[1, 2]
173ATNNNEAKNGI****ubiquitination[3]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 176 AA 
Protein Sequence
MMVNCHAHFW TTKAFLPTML EINHGHIVTV ASSLGLFSTA GVEDYCASKF GVVGFHESLS 60
HELKAAEKDG IKTTLVCPYL VDTGMFRGCR IRKEIEPFLP PLKPDYCVKQ AMKAILTDQP 120
MICTPRLMYI VTFMKSILPF EAVVCMYRFL GADKCMYPFI AQRKQATNNN EAKNGI 176 
Gene Ontology
 GO:0044297; C:cell body; IEA:Compara.
 GO:0016020; C:membrane; IEA:Compara.
 GO:0052650; F:NADP-retinol dehydrogenase activity; IEA:Compara.
 GO:0004745; F:retinol dehydrogenase activity; IEA:Compara.
 GO:0060449; P:bud elongation involved in lung branching; IEA:Compara.
 GO:0043583; P:ear development; IEA:Compara.
 GO:0031076; P:embryonic camera-type eye development; IEA:Compara.
 GO:0035115; P:embryonic forelimb morphogenesis; IEA:Compara.
 GO:0048703; P:embryonic viscerocranium morphogenesis; IEA:Compara.
 GO:0008406; P:gonad development; IEA:Compara.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0001656; P:metanephros development; IEA:Compara.
 GO:0014032; P:neural crest cell development; IEA:Compara.
 GO:0043584; P:nose development; IEA:Compara.
 GO:0055114; P:oxidation-reduction process; IEA:GOC.
 GO:0060431; P:primary lung bud formation; IEA:Compara.
 GO:0042574; P:retinal metabolic process; IEA:Compara.
 GO:0002138; P:retinoic acid biosynthetic process; IEA:Compara. 
Interpro
 IPR002198; DH_sc/Rdtase_SDR.
 IPR002347; Glc/ribitol_DH.
 IPR016040; NAD(P)-bd_dom.
 IPR020904; Sc_DH/Rdtase_CS. 
Pfam
 PF00106; adh_short 
SMART
  
PROSITE
 PS00061; ADH_SHORT 
PRINTS
 PR00081; GDHRDH.