CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038923
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Dock8 
Protein Synonyms/Alias
  
Gene Name
 Dock8 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
1929MHAFPYIKTRIRVSQacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2099 AA 
Protein Sequence
MATLPSAERR AFALKINRYS SSEIRKQFTL PPNLGQYHRH SLSTSGFPSL QLPQLYEPVE 60
PVDFEGLVMT HLNSLDAELA QELGDLTDDD LHVAFTPKEC RTLQHSLPEE GVELDPHVRD 120
CVQTYIREWL IVNRKNQGSP EFCSFRKTGS RRDFHKTLQK QTFESETLEC SEPATQTGPR 180
HRFNVLCDVS GKGPITSCDF DLRSLQPDER LENLLQLSAE DFEKEKEEAR KTNRTAELFA 240
LYPSVDEEDA VEIRPVPECP KEHLGNRILV KVLTLKFEIE IEPLFASIAL YDVKERKKIS 300
ENFHCDLNSD QFKGFLRAHT PSVDPSSQAR SAVFSVTYPS SDIYLVVKIE KVLQQGEIAD 360
CAEPYMIIKE SDGGKSKEKV EKLKLQAESF CQRLGKYRMP FAWAPISLAS FFNVSTLERE 420
STDLEPGAGR NSVGERRSLS QSRRPSERTL SFEENGVGSN FKTTTLATNI FFKQEGDRLS 480
DEDLFKFLAD YKRSSSLQRR VKSIPGSLRL EIAPAPDVMN CCLTPEMLPV KPFPENRTRP 540
HKEILEFPIR EVYVPHTVYR NLLYVYPQRL NFANKLASAR NITIKIQFMC GEDPSNAMPV 600
IFGKSSGPEF LQEVYTAITY HNKSPDFYEE VKIKLPAKLT VNHHLLFTFY HISCQQKQGA 660
SGESLLGYSW LPILLNERLQ TGSYCLPVAL EKLPPNYSIH SAEKVPLQNP PIKWAEGHKG 720
VFNIEVQAVS SVHTQDNHLE KFFTLCHSLE SQVTFPIRVL DQKITENTLE HELKLSIICL 780
NSSRLEPLVL FLHLVLDKLF QLSVQPMVIA GQTANFSQFA FESVVAIANS LHNSKDLRKD 840
QHGRNCLLAS YVHYVFRLPE LHRDAPKSGG PTAVVPDPRY HTYGRTSAAA VSSKLMQARV 900
MSSSNPDLAG THCAADEEVK NIMSSKIADR NCSRMSYYCS GNSDVPGSTA APRPVSKKHF 960
HEELALQMVV STGLVRETVF KYAWFFFELL VKSMAQYVHN LDKRDSFRRT RFSDRFKDDI 1020
TTIVNVVTSE IAALLVKPQK ESEQAEKINI SLAFFLYDLL SIMDRGFVFN LIKHYCTQLS 1080
AKLNTLPTLI SMRLEFLRIL CSHEHYLNLN LLFMNPDTAP ASPCPSISSQ NSSSCSSFQD 1140
QKIASMFDLT PEYRQQHFLT GLLFTELAVA LDAEGDGISR VQRKAVSAIH SLLSSHDLDP 1200
RCLKPEVKVK IAALYLPLVG IILDALPQLY DFTDARSGRS RASGSYEEQD VANGINQNVA 1260
LAIAGNHFNL KTSGAMLSSL PYKQYNMLNA DTTRHLMVCF LWIMKNADQS LIRKWIADLP 1320
SMQLNRILDL LFICVSCFEY KGKQSSDKVS NQVLQKSRDV KAKLEEALLR GEGARGEMMR 1380
RRIPGTDRFP GLNENLRWRK EQTQWRQANE KLDKTKAELD QEALISGNLA TEANLIILDM 1440
QENIIQASSS LDCKDSLLGG VLRVLVNSLS CDQSTTYLTH CFATLRALIA KFGDLLFEEE 1500
MEQCADLCQR VLHHCSSSMD VTRSQACATL YLLMRFSFGA TSNFARVKMQ VTMALASLVG 1560
KAPDFNEEHL RKSLRTILAY SEEDTAMRAT LFPTQVEELL CNLNSILYDT VKMREFQEDP 1620
EMLMDLMYRI AKSYQASPDL RLTWLQNMAE KHTKRKCFTE AAMCLVHAAA LVAEYLSMLE 1680
DHSYLPVGSV SFQNISSNVL EESAVSDDTL SPDEDGVCSG RYFTESGLVG LLEQAAELFS 1740
TGGLYETVNE VYKLVIPILE AHRDFRKLTS THDKLQKAFD NIINKDHKRM FGTYFRVGFY 1800
GSKFGDLDEQ EFVYKEPAIT KLPEISHRLE GFYGQCFGAE FVEVIKDSTP VDKTKLDPNK 1860
AYIQITFVEP YFDEYEMKDR VTYFEKNFNL RRFMYTTPFT LEGRPRGELH EQHRRNTVLT 1920
TMHAFPYIKT RIRVSQKEEF VLTPIEVAIE DMKKKTLQLA VATHQEPPDA KMLQMVLQGS 1980
VGATVNQGPL EVAQVFLAEI PADPKLYRHH NKLRLCFKEF IMRCGEAVEK NRRLITAEQR 2040
EYQQELKKNY NRLKDSLRPM IERKIPELYK PIFRVDSQKR DSFHRSSFRK CETQLSQGS 2099 
Gene Ontology
 GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 
Interpro
 IPR016024; ARM-type_fold.
 IPR027007; DHR-1_domain.
 IPR027357; DHR-2.
 IPR026791; DOCK.
 IPR010703; DOCK_C.
 IPR021816; DOCK_C/D_N.
 IPR026798; DOCK_C_fam. 
Pfam
 PF06920; Ded_cyto
 PF14429; DOCK-C2
 PF11878; DUF3398 
SMART
  
PROSITE
 PS51650; DHR_1
 PS51651; DHR_2 
PRINTS