CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038388
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Bromodomain adjacent to zinc finger domain protein 2A 
Protein Synonyms/Alias
  
Gene Name
 Baz2a 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
789RPSCRADKTLATQKRacetylation[1]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
  
Sequence Annotation
  
Keyword
 Bromodomain; Complete proteome; Metal-binding; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1888 AA 
Protein Sequence
MEANDHFNFT GLPPAPAASG LKPSPSSGEG LYTNGSPMNF PQQGKSLNGD VNVNGLSTVS 60
HTTTSGILNS APHSSSTSHL HHPNVAYDCL WNYSQYPSAN PGNNLKDPPL LSQFPGGQYP 120
LNGILGGNRQ PSSPSHNTNL RAGSQEFWAN GTQSPMGLNF DSQELYDSFP DQNFEVMPNG 180
PPSFFTSPQT SPMLGSSIQT FAPSQDVSSD IHPDEAAEKE LTSVVAENGT GLVGSLELEE 240
EQPELKMCGY NGSVSSVESL HQEVSVLVPD PTVSCLDDPS HLPDQLEDTP ILSEDSLEPF 300
DSLAAAEPVS GSLYGIDDAE LMGAEDKLPL EGNPVISALD CPALSNANAF SLLADDSQTS 360
ASIFVSPTSP PVLGESVLQD NSFGLNSCSD SEQEEIETQS SNFQRPLTEP APDQPPSTQL 420
HPAVSPTASP AASLTASAEI SPAVSPVASS PVPPEVFVAV SPASSPALPA ISLEASMTTP 480
VTSPQGSPEP SPAAAFQTVS PARKNVSSAP KARADREETT GGAVAVSGSG DVLKRRIATP 540
EEVRLPLQHG WRREVRIKKG SHRWQGETWY YGPCGKRMKQ FPEVIKYLSR NVVHSVRREH 600
FSFSPRMPVG DFFEERDTPE GLQWVQLSAE EIPSRIQAIT GKRGRPRNNE KAKNKEVPKV 660
KRGRGRPPKI KMPELLNKTD NRLPKKLETQ EILSEDDKAK MTKNKKKMRQ KVQRGESQTP 720
VQGQARNKRK QDTKSLKQKD TKKKLKAEKE KMKTKQEKLK EKVKREKKEK VKAKGKEGPR 780
ARPSCRADKT LATQKRLEEQ QRQQAILEEM KKPTEDMCLS DHQPLPDFTR IPGLTLSSRA 840
FSDCLTIVEF LHSFGKVLGF DLTKDVPSLG VLQEGLLCQG DSLDKVQDLL VRLLKAALHD 900
PGLPPYCQSL KILGEKMSEI PLTRDNVSEI LRCFLMAYRV EPSFCDSLRT QPFQAQPPQQ 960
KAAILAFLVH ELNSSTIIIN EIDKTLESVS SCRKNKWIVE GRLRRLKTAL AKRTGRPEVM 1020
MEGAEDGLGR RRSSRIMEET SGIEEEEEEE NTTAVHGRRG RKEGEIDVAA SSIPELERHI 1080
EKLSKRQLFF RKKLLHSSQM LRAVSLGQDR YRRHYWVLPY LAGIFVEGSE GSTVTEDEIK 1140
QETESLMEVV TSTPSSARAS VKRELTGSNA STSPARSRGR PRKPKPGSLQ PQHLQSTIRE 1200
CDSEQAQTQV HPEPQPQLQA PTQPHLQPSS GFLEPEGSPF SLGQSQHDLS QSAFLSWLSQ 1260
TQSHNSLLSS SVLTPDSSPG KLDSAPSQSL EEPEPDEAQS CPGPQGPWFN FSAQIPCDAA 1320
PTPPPAVSED QPTPSLQLLA SSKPMNTPGA ANPCSPVQLS STHLPGGTPK RLSGDSEEMS 1380
QSPTGLGQPK RRGRPPSKFF KQVEQHYLTQ LTAQPIPPEM CSGWWWIRDP ETLDVLLKAL 1440
HPRGIREKAL HKHLSKHKDF LQEVCLQPLT DPIFEPNELP ALEEGVMSWS PKEKTYETDL 1500
AVLQWVEELE QRVVLSDLQI RGWTCPTPDS TREDLTYCEH LPDSPEDIPW RGRGREGTVP 1560
QRQNNNPLDL AVMRLAVLEQ NVERRYLREP LWAAHEVVVE KALLSTPNGA PDGTSTEISY 1620
EITPRVRVWR QTLERCRSAA QVCLCMGQLE RSIAWEKSVN KVTCLVCRKG DNDEFLLLCD 1680
GCDRGCHIYC HRPKMEAVPE GDWFCAVCLS QQVEEEYTQR PGFPKRGQKR KSSFPLTFPE 1740
GDSRRRMLSR SRDSPAVPRY PEDGLSPPKR RRHSMRSHHS DLTFCEIILM EMESHDAAWP 1800
FLEPVNPRLV SGYRRVIKNP MDFSTMRERL LRGGYTSSEE FAADALLVFD NCQTFNEDDS 1860
EVGKAGHVMR RFFESRWEEF YQGKQANL 1888 
Gene Ontology
 GO:0005730; C:nucleolus; IDA:MGI.
 GO:0003677; F:DNA binding; IDA:MGI.
 GO:0003723; F:RNA binding; IDA:MGI.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0000183; P:chromatin silencing at rDNA; IDA:MGI.
 GO:0070869; P:heterochromatin assembly involved in chromatin silencing; IDA:MGI.
 GO:0051567; P:histone H3-K9 methylation; IDA:MGI.
 GO:0070933; P:histone H4 deacetylation; IDA:MGI.
 GO:0034770; P:histone H4-K20 methylation; IDA:MGI. 
Interpro
 IPR017956; AT_hook_DNA-bd_motif.
 IPR001487; Bromodomain.
 IPR018359; Bromodomain_CS.
 IPR004022; DDT_dom.
 IPR018500; DDT_dom_subgr.
 IPR018501; DDT_dom_superfamily.
 IPR016177; DNA-bd_integrase-typ.
 IPR001739; Methyl_CpG_DNA-bd.
 IPR011011; Znf_FYVE_PHD.
 IPR001965; Znf_PHD.
 IPR019787; Znf_PHD-finger.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF00439; Bromodomain
 PF02791; DDT
 PF01429; MBD
 PF00628; PHD 
SMART
 SM00384; AT_hook
 SM00297; BROMO
 SM00571; DDT
 SM00391; MBD
 SM00249; PHD 
PROSITE
 PS00633; BROMODOMAIN_1
 PS50014; BROMODOMAIN_2
 PS50827; DDT
 PS50982; MBD
 PS50016; ZF_PHD_2 
PRINTS
 PR00503; BROMODOMAIN.