CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009092
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Synaptojanin-2-binding protein 
Protein Synonyms/Alias
 Mitochondrial outer membrane protein 25 
Gene Name
 SYNJ2BP 
Gene Synonyms/Alias
 OMP25 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
48GIYVSRIKENGAAALubiquitination[1]
64GRLQEGDKILSVNGQubiquitination[1, 2, 3, 4]
74SVNGQDLKNLLHQDAubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
  
Sequence Annotation
 DOMAIN 13 100 PDZ.  
Keyword
 3D-structure; Complete proteome; Membrane; Mitochondrion; Mitochondrion outer membrane; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 145 AA 
Protein Sequence
MNGRVDYLVT EEEINLTRGP SGLGFNIVGG TDQQYVSNDS GIYVSRIKEN GAAALDGRLQ 60
EGDKILSVNG QDLKNLLHQD AVDLFRNAGY AVSLRVQHRL QVQNGPIGHR GEGDPSGIPI 120
FMVLVPVFAL TMVAAWAFMR YRQQL 145 
Gene Ontology
 GO:0009986; C:cell surface; IEA:Compara.
 GO:0031307; C:integral to mitochondrial outer membrane; IEA:Compara.
 GO:0005739; C:mitochondrion; IDA:UniProtKB.
 GO:0048312; P:intracellular distribution of mitochondria; IEA:Compara.
 GO:0032926; P:negative regulation of activin receptor signaling pathway; IEA:Compara.
 GO:0032927; P:positive regulation of activin receptor signaling pathway; IEA:Compara.
 GO:2000010; P:positive regulation of protein localization to cell surface; IEA:Compara.
 GO:0002092; P:positive regulation of receptor internalization; IEA:Compara. 
Interpro
 IPR001478; PDZ. 
Pfam
 PF00595; PDZ 
SMART
 SM00228; PDZ 
PROSITE
 PS50106; PDZ 
PRINTS