UniProt Accession

 HM20A_HUMAN; Q9NP66; A6NHY3; D3DW78; Q53G31; Q9NSF6 

Genbank Protein ID

 AF146222; AL355736; AL355737; AK001601; BT006716; AK223100; AC090984; CH471136; CH471136; CH471136; BC021959 

Genbank Nucleotide ID

 AAF66706.1; CAB90815.1; CAB90816.1; BAA91782.1; AAP35362.1; BAD96820.1; EAW99201.1; EAW99202.1; EAW99203.1; AAH21959.1 

Protein Name

 High mobility group protein 20A 

Protein Synonyms/Alias

 HMG box-containing protein 20A; HMG domain-containing protein 1; HMG domain-containing protein HMGX1 

Gene Name

 HMG20A 

Gene Synonyms/Alias

 HMGX1; HMGXB1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
177	YQKTEAYKVFSRKTQ	ubiquitination	[1]
230	EEFLNHSKAREAELR	ubiquitination	[2]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Plays a role in neuronal differentiation as chromatin- associated protein. Acts as inhibitor of HMG20B. Overcomes the repressive effects of the neuronal silencer REST and induces the activation of neuronal-specific genes. Involved in the recruitment of the histone methyltransferase KMT2A/MLL1 and consequent increased methylation of histone H3 lysine 4 (By similarity). 

Sequence Annotation

 DNA_BIND 103 171 HMG box.
 MOD_RES 105 105 Phosphoserine.  

Keyword

 Alternative splicing; Chromatin regulator; Coiled coil; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 347 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; NAS:UniProtKB.
 GO:0003677; F:DNA binding; NAS:UniProtKB.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; NAS:UniProtKB.
 GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.
 GO:0006325; P:chromatin organization; NAS:UniProtKB.
 GO:0045665; P:negative regulation of neuron differentiation; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR009071; HMG_box_dom. 

Pfam

 PF00505; HMG_box 

SMART

 SM00398; HMG 

PROSITE

 PS00353; HMG_BOX_1
 PS50118; HMG_BOX_2 

PRINTS