UniProt Accession

 SNX5_MOUSE; Q9D8U8; Q543N9 

Genbank Protein ID

 AK007676; AK029463; AK031873; AK049129; AK159904; AK169786; BC002242 

Genbank Nucleotide ID

 BAB25180.1; BAC26460.1; BAC27587.1; BAC33558.1; BAE35468.1; BAE41365.1; AAH02242.1 

Protein Name

 Sorting nexin-5 

Protein Synonyms/Alias

  

Gene Name

 Snx5 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
17	QQEEDRSKLRSVSVD	ubiquitination	[1]
118	EGEGSMTKEEFAKMK	ubiquitination	[1]
180	SVRRKNTKEMFGGFF	ubiquitination	[1]
188	EMFGGFFKSVVKSAD	ubiquitination	[1]
268	VIKKYLLKVAELFEK	ubiquitination	[1]
275	KVAELFEKLRKVEGR	acetylation	[2, 3]
275	KVAELFEKLRKVEGR	ubiquitination	[1]
290	VSSDEDLKLTELLRY	ubiquitination	[1]
337	RLKSKDVKLAETHQQ	ubiquitination	[1]
349	HQQECCQKFEQLSES	acetylation	[2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 May be involved in several stages of intracellular trafficking. Plays a role in macropinocytosis. Plays a role in the internalization of EGFR after EGF stimulation (By similarity). 

Sequence Annotation

 DOMAIN 25 172 PX.
 DOMAIN 202 404 BAR.
 REGION 40 46 Phosphatidylinositol bisphosphate binding
 REGION 99 105 Phosphatidylinositol bisphosphate binding
 REGION 113 116 Phosphatidylinositol bisphosphate binding
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 275 275 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Cell membrane; Cell projection; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Endocytosis; Endosome; Lipid-binding; Membrane; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 404 AA 

Protein Sequence

Gene Ontology

 GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
 GO:0031313; C:extrinsic to endosome membrane; ISS:UniProtKB.
 GO:0031234; C:extrinsic to internal side of plasma membrane; ISS:UniProtKB.
 GO:0070685; C:macropinocytic cup; ISS:UniProtKB.
 GO:0001891; C:phagocytic cup; IEA:UniProtKB-SubCell.
 GO:0001726; C:ruffle; IEA:UniProtKB-SubCell.
 GO:0035091; F:phosphatidylinositol binding; ISS:UniProtKB.
 GO:0007154; P:cell communication; IEA:InterPro.
 GO:0006907; P:pinocytosis; ISS:UniProtKB.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 

Interpro

 IPR001683; Phox.
 IPR014637; Snx5_Snx6.
 IPR015404; Vps5_C. 

Pfam

 PF00787; PX
 PF09325; Vps5 

SMART

 SM00312; PX 

PROSITE

 PS51021; BAR
 PS50195; PX 

PRINTS