CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014228
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nuclear factor of activated T-cells, cytoplasmic 2 
Protein Synonyms/Alias
 NF-ATc2; NFATc2; NFAT pre-existing subunit; NF-ATp; T-cell transcription factor NFAT1 
Gene Name
 Nfatc2 
Gene Synonyms/Alias
 Nfat1; Nfatp 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
684YHPVPAIKTEPSDEYsumoylation[1]
897LPTGVTVKQEQNLDQsumoylation[1]
Reference
 [1] Dual role of sumoylation in the nuclear localization and transcriptional activation of NFAT1.
 Terui Y, Saad N, Jia S, McKeon F, Yuan J.
 J Biol Chem. 2004 Jul 2;279(27):28257-65. [PMID: 15117942] 
Functional Description
 Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF. Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway (By similarity). 
Sequence Annotation
 REPEAT 186 202 1.
 REPEAT 215 231 2.
 REPEAT 274 290 3; approximate.
 DOMAIN 394 576 RHD.
 DNA_BIND 423 430
 REGION 111 116 Calcineurin-binding.
 REGION 119 201 Trans-activation domain A (TAD-A).
 REGION 163 177 Required for cytoplasmic retention of the
 REGION 186 292 3 X approximate SP repeats.
 MOTIF 253 255 Nuclear localization signal.
 MOD_RES 53 53 Phosphoserine (Probable).
 MOD_RES 54 54 Phosphoserine (Probable).
 MOD_RES 56 56 Phosphoserine (Probable).
 MOD_RES 99 99 Phosphoserine.
 MOD_RES 136 136 Phosphoserine.
 MOD_RES 150 150 Phosphoserine (By similarity).
 MOD_RES 170 170 Phosphoserine (Probable).
 MOD_RES 173 173 Phosphoserine (Probable).
 MOD_RES 174 174 Phosphoserine (Probable).
 MOD_RES 176 176 Phosphoserine (Probable).
 MOD_RES 177 177 Phosphoserine (Probable).
 MOD_RES 179 179 Phosphoserine (Probable).
 MOD_RES 182 182 Phosphoserine (Probable).
 MOD_RES 215 215 Phosphoserine.
 MOD_RES 219 219 Phosphoserine.
 MOD_RES 223 223 Phosphoserine.
 MOD_RES 238 238 Phosphoserine.
 MOD_RES 245 245 Phosphoserine.
 MOD_RES 270 270 Phosphoserine.
 MOD_RES 276 276 Phosphoserine.
 MOD_RES 278 278 Phosphoserine.
 MOD_RES 282 282 Phosphoserine.
 MOD_RES 328 328 Phosphoserine.
 MOD_RES 365 365 Phosphoserine.
 MOD_RES 757 757 Phosphoserine (By similarity).
 MOD_RES 759 759 Phosphoserine (By similarity).
 MOD_RES 761 761 Phosphoserine (By similarity).  
Keyword
 Activator; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 927 AA 
Protein Sequence
MDVPEPQPDP DGGDGPGHEP GGSPQDELDF SILFDYDYLN PIEEEPIAHK AISSPSGLAY 60
PDDVLDYGLK PCNPLASLSG EPPGRFGEPD SIGFQNFLSP VKPAGASGPS PRIEITPSHE 120
LMQAGGALRG RDAGLSPEQP ALALAGVAAS PRFTLPVPGY EGYREPLCLS PASSGSSASF 180
ISDTFSPYTS PCVSPNNAGP DDLCPQFQNI PAHYSPRTSP IMSPRTSLAE DSCLGRHSPV 240
PRPASRSSSP GAKRRHSCAE ALVAPLPAAS PQRSRSPSPQ PSPHVALQDD SIPAGYPPTA 300
GSAVLMDALN TLATDSPCGI PSKIWKTSPD PTPVSTAPSK AGLARHIYPT VEFLGPCEQE 360
ERRNSAPESI LLVPPTWPKQ LVPAIPICSI PVTASLPPLE WPLSNQSGSY ELRIEVQPKP 420
HHRAHYETEG SRGAVKAPTG GHPVVQLHGY MENKPLGLQI FIGTADERIL KPHAFYQVHR 480
ITGKTVTTTS YEKIVGNTKV LEIPLEPKNN MRATIDCAGI LKLRNADIEL RKGETDIGRK 540
NTRVRLVFRV HVPEPSGRIV SLQAASNPIE CSQRSAHELP MVERQDMDSC LVYGGQQMIL 600
TGQNFTAESK VVFMEKTTDG QQIWEMEATV DKDKSQPNML FVEIPEYRNK HIRVPVKVNF 660
YVINGKRKRS QPQHFTYHPV PAIKTEPSDE YEPSLICSPA HGGLGSQPYY PQHPMLAESP 720
SCLVATMAPC QQFRSGLSSP DARYQQQSPA AALYQRSKSL SPGLLGYQQP SLLAAPLGLA 780
DAHRSVLVHA GSQGQGQGST LPHTSSASQQ ASPVIHYSPT NQQLRGGGHQ EFQHIMYCEN 840
FGPSSARPGP PPINQGQRLS PGAYPTVIQQ QTAPSQRAAK NGPSDQKEAL PTGVTVKQEQ 900
NLDQTYLDDV NEIIRKEFSG PPSRNQT 927 
Gene Ontology
 GO:0015629; C:actin cytoskeleton; IEA:Compara.
 GO:0005829; C:cytosol; IDA:MGI.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0030529; C:ribonucleoprotein complex; IDA:MGI.
 GO:0005667; C:transcription factor complex; IPI:MGI.
 GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:MGI.
 GO:0044212; F:transcription regulatory region DNA binding; IDA:UniProtKB.
 GO:0050853; P:B cell receptor signaling pathway; IEA:Compara.
 GO:0016477; P:cell migration; ISS:UniProtKB.
 GO:0001816; P:cytokine production; IDA:MGI.
 GO:0030890; P:positive regulation of B cell proliferation; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0006974; P:response to DNA damage stimulus; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR013783; Ig-like_fold.
 IPR014756; Ig_E-set.
 IPR002909; IPT_TIG_rcpt.
 IPR008366; NFAT.
 IPR008967; p53-like_TF_DNA-bd.
 IPR011539; RHD. 
Pfam
 PF00554; RHD
 PF01833; TIG 
SMART
 SM00429; IPT 
PROSITE
 PS01204; REL_1
 PS50254; REL_2 
PRINTS
 PR01789; NUCFACTORATC.