CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000585
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Peptidyl-prolyl cis-trans isomerase FKBP8 
Protein Synonyms/Alias
 PPIase FKBP8; 38 kDa FK506-binding protein; 38 kDa FKBP; FKBP-38; mFKBP38; FK506-binding protein 8; FKBP-8; FKBPR38; Rotamase 
Gene Name
 Fkbp8 
Gene Synonyms/Alias
 Fkbp38; Sam11 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
102KTLVPGPKGSSRPLKubiquitination[1]
262EEELLQLKVKCLNNLubiquitination[1]
275NLAASQLKLDHYRAAubiquitination[1]
298EHQPDNIKALFRKGKubiquitination[1]
305KALFRKGKVLAQQGEubiquitination[1]
325PILRAALKLEPSNKTubiquitination[1]
331LKLEPSNKTIHAELSubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis (By similarity). Required for normal embryonic development. 
Sequence Annotation
 DOMAIN 110 194 PPIase FKBP-type.
 REPEAT 211 244 TPR 1.
 REPEAT 262 295 TPR 2.
 REPEAT 296 329 TPR 3.  
Keyword
 Alternative splicing; Apoptosis; Calcium; Complete proteome; Isomerase; Membrane; Mitochondrion; Reference proteome; Repeat; Rotamase; TPR repeat; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 402 AA 
Protein Sequence
MASWAEPSEP AALRLPGAPL LEGFEVLDGV DDAEEEDDLS GLPPLEDMGQ PTVEEAEQPG 60
ALAREFLAAT EPEPAPAPAP EEWLDILGNG LLRMKTLVPG PKGSSRPLKG QVVTVHLQMS 120
LENGTRVQEE PELAFTLGDC DVIQALDLSV PLMDVGETAM VTADSKYCYG PQGSRSPYIP 180
PHAALCLEVT LKTAEDGPDL EMLSGQERVA LANRKRECGN AHYQRADFVL AANSYDLAIK 240
AITSNTKVDM TCEEEEELLQ LKVKCLNNLA ASQLKLDHYR AALRSCSQVL EHQPDNIKAL 300
FRKGKVLAQQ GEYSEAIPIL RAALKLEPSN KTIHAELSKL VKKRAAQRST ETALYRKMLG 360
NPSRLPAKCP GKGAWSIPWK WLFGATAVAL GGVALSVVIA ARN 403 
Gene Ontology
 GO:0030176; C:integral to endoplasmic reticulum membrane; IDA:MGI.
 GO:0005740; C:mitochondrial envelope; IDA:MGI.
 GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
 GO:0005528; F:FK506 binding; IBA:RefGenome.
 GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IBA:RefGenome.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0043010; P:camera-type eye development; IMP:MGI.
 GO:0001708; P:cell fate specification; IMP:MGI.
 GO:0021904; P:dorsal/ventral neural tube patterning; IDA:MGI.
 GO:0035264; P:multicellular organism growth; IGI:MGI.
 GO:0030513; P:positive regulation of BMP signaling pathway; IMP:MGI.
 GO:0006457; P:protein folding; IEA:UniProtKB-KW.
 GO:0010468; P:regulation of gene expression; IGI:MGI.
 GO:0007224; P:smoothened signaling pathway; IMP:MGI. 
Interpro
 IPR023114; Elongated_TPR_rpt_dom.
 IPR023566; PPIase_FKBP.
 IPR001179; PPIase_FKBP_dom.
 IPR001440; TPR-1.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR019734; TPR_repeat. 
Pfam
 PF00254; FKBP_C
 PF00515; TPR_1 
SMART
  
PROSITE
 PS50059; FKBP_PPIASE
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS