UniProt Accession

 CBPA6_HUMAN; Q8N4T0; Q8NEX8; Q8TDE8; Q9NRI9 

Genbank Protein ID

 AF466284; BK000188; AY044833; AF221594; BC033684 

Genbank Nucleotide ID

 AAM19307.1; DAA00037.1; AAK84941.1; AAF91231.1; AAH33684.1 

Protein Name

 Carboxypeptidase A6 

Protein Synonyms/Alias

 Carboxypeptidase B 

Gene Name

 CPA6 

Gene Synonyms/Alias

 CPAH 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
129	ANRNWKVKWCDVSSG	ubiquitination	[1]
144	SSMDWAYKNGIPYAF	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 May be involved in the proteolytic inactivation of enkephalins and neurotensin in some brain areas. May convert inactive angiotensin I into the biologically active angiotensin II. 

Sequence Annotation

 REGION 196 199 Substrate binding (By similarity).
 REGION 271 272 Substrate binding (By similarity).
 REGION 325 326 Substrate binding (By similarity).
 ACT_SITE 398 398 Nucleophile (By similarity).
 METAL 196 196 Zinc; catalytic (By similarity).
 METAL 199 199 Zinc; catalytic (By similarity).
 METAL 324 324 Zinc; catalytic (By similarity).
 BINDING 254 254 Substrate (By similarity).
 CARBOHYD 89 89 N-linked (GlcNAc...) (Potential).
 CARBOHYD 153 153 N-linked (GlcNAc...) (Potential).
 CARBOHYD 427 427 N-linked (GlcNAc...) (Potential).
 DISULFID 265 288 By similarity.  

Keyword

 Alternative splicing; Carboxypeptidase; Chromosomal rearrangement; Cleavage on pair of basic residues; Complete proteome; Disease mutation; Disulfide bond; Epilepsy; Extracellular matrix; Glycoprotein; Hydrolase; Metal-binding; Metalloprotease; Polymorphism; Protease; Reference proteome; Secreted; Signal; Zinc; Zymogen. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 437 AA 

Protein Sequence

Gene Ontology

 GO:0005578; C:proteinaceous extracellular matrix; IEA:UniProtKB-SubCell.
 GO:0004181; F:metallocarboxypeptidase activity; NAS:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW. 

Interpro

 IPR000834; Peptidase_M14.
 IPR003146; Prot_inh_M14A.
 IPR009020; Prot_inh_propept. 

Pfam

 PF00246; Peptidase_M14
 PF02244; Propep_M14 

SMART

 SM00631; Zn_pept 

PROSITE

 PS00132; CARBOXYPEPT_ZN_1
 PS00133; CARBOXYPEPT_ZN_2 

PRINTS

 PR00765; CRBOXYPTASEA.