CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043712
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Integrin alpha-6 heavy chain 
Protein Synonyms/Alias
  
Gene Name
 ITGA6 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
67RESHNSRKKREITEKubiquitination[1]
114PLRGLDSKASLILRSubiquitination[2]
250EKKQWITKWNENESYubiquitination[1, 3]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 258 AA 
Protein Sequence
TSNQDNLAPI TAKAKVVIEL LLSVSGVAKP SQVYFGGTVV GEQAMKSEDE VGSLIEYEFR 60
ESHNSRKKRE ITEKQIDDNR KFSLFAERKY QTLNCSVNVN CVNIRCPLRG LDSKASLILR 120
SRLWNSTFLE EYSKLNYLDI LMRAFIDVTA AAENIRLPNA GTQVRVTVFP SKTVAQYSGV 180
PWWIILVAIL AGILMLALLV FILWKCGFFK RSRYDDSVPR YHAVRIRKEE REIKDEKYID 240
NLEKKQWITK WNENESYS 258 
Gene Ontology
  
Interpro
 IPR013649; Integrin_alpha-2.
 IPR018184; Integrin_alpha_C_CS. 
Pfam
 PF08441; Integrin_alpha2 
SMART
  
PROSITE
 PS00242; INTEGRIN_ALPHA 
PRINTS