UniProt Accession

 HEMG_ECOLI; P0ACB4; P27863; Q2M8F3 

Genbank Protein ID

 X54687; X68660; M87049; U00096; AP009048 

Genbank Nucleotide ID

 CAA48626.1; AAA67647.1; AAC76853.1; BAE77453.1 

Protein Name

 Protoporphyrinogen IX dehydrogenase [menaquinone] 

Protein Synonyms/Alias

  

Gene Name

 hemG 

Gene Synonyms/Alias

 yihB; b3850; JW3827 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
26	SYLASELKELGIQAD	acetylation	[1]
71	SAFQEFVKKHATRLN	acetylation	[1]
154	GGETDTRKEVVYTDW	acetylation	[1]
177	EIAHLTDKPTLK***	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX using menaquinone as electron acceptor. 

Sequence Annotation

 DOMAIN 3 172 Flavodoxin-like.  

Keyword

 Complete proteome; Direct protein sequencing; Oxidoreductase; Porphyrin biosynthesis; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 181 AA 

Protein Sequence

Gene Ontology

 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0010181; F:FMN binding; IDA:EcoCyc.
 GO:0070819; F:menaquinone-dependent protoporphyrinogen oxidase activity; IDA:EcoCyc.
 GO:0004729; F:oxygen-dependent protoporphyrinogen oxidase activity; IDA:EcoCyc.
 GO:0006783; P:heme biosynthetic process; IMP:EcoCyc.
 GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway. 

Interpro

 IPR008254; Flavodoxin/NO_synth.
 IPR001226; Flavodoxin_CS.
 IPR026816; Flavodoxin_dom. 

Pfam

 PF12724; Flavodoxin_5 

SMART

  

PROSITE

 PS00201; FLAVODOXIN
 PS50902; FLAVODOXIN_LIKE 

PRINTS