Tag | Content |
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CPLM ID | CPLM-012950 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Leucine zipper putative tumor suppressor 2 |
Protein Synonyms/Alias | Protein LAPSER1 |
Gene Name | Lzts2 |
Gene Synonyms/Alias | Lapser1 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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133 | KLIPVSGKLEKNMEK | acetylation | [1] |
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Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin (By similarity). |
Sequence Annotation | REGION 1 333 Required for centrosomal localization (By REGION 448 670 Sufficient for interaction with CTNNB1 REGION 451 670 Sufficient for interaction with KATNB1 MOTIF 632 641 Nuclear export signal (By similarity). MOD_RES 571 571 Phosphoserine (By similarity). |
Keyword | Cell cycle; Cell division; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Microtubule; Mitosis; Phosphoprotein; Reference proteome; Wnt signaling pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 670 AA |
Protein Sequence | MAIVQTLPVP LEPARETATA PQTPAMGSVS SLISGRPCPG GPAPQRHHGV PGPTFFRQQD 60 GLLRGGYEAQ EPLCPAVPPR KTVPGNSFTY VNEDFRTESP PSPSSDVEDP REHQAHNAHL 120 RGPPPKLIPV SGKLEKNMEK ILIRPTAFKP VLPKPRGAPS LPGFLGPRAA GLSGSQGSLT 180 QLFGGPASSS SSSSSSSAAD KPLALSGWAS GCPSGTLSDS GRNSLSSLPT YSTGGAEPTA 240 NSPGGHLPSH GPGRGPLPGP ARGVPTGPSH SDSGRSSSSK STGSLGARVA GGLLGSGARA 300 SPGSSSGGDR SPPPPPPPPP SDEALLHCVL EGKLRDREAE LQQLRDSVDE SEAAVCQAFG 360 ARQRRWPGER EDCASHAQQA TQRVQRAQQL LQLQVFQLQQ EKRQLQDDFA QLLQEREQLE 420 RRCATFEREQ QELGPRLEET KWEVCQKSGE ISLLKQQLKE SQAELVQKGS ELVALRVALR 480 EARAALRVSE GHARGLQEAA RARELELEAC SQELQRYRQE AEQLREKARH LDAEAAGLRE 540 PPVPPATTDP FLLAESDEAK VQRAAAGTGG SLRAQVERLR QELQREQRRG DEQRNSFEGE 600 RLAWQAEKEQ VIRYQKQLQH NYVQMYRRNR QLEQELQQLS LELEARELAD LGLSEPAPCI 660 CLEEITATEI 670 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005874; C:microtubule; IEA:UniProtKB-KW. GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell. GO:0030496; C:midbody; IDA:RGD. GO:0051301; P:cell division; IEA:UniProtKB-KW. GO:0007067; P:mitosis; IEA:UniProtKB-KW. GO:0010942; P:positive regulation of cell death; IDA:RGD. GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. |
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