CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028829
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Tumor suppressor p53-binding protein 1 
Protein Synonyms/Alias
  
Gene Name
 Trp53bp1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
247PVTVQPGKGIHVVEEacetylation[1]
1573LDNLVEGKRKRRSNIacetylation[2]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1919 AA 
Protein Sequence
MPGEQMDPTG SQLDSDFSQQ DTPCLIIEDS QPESQVLEED AGSHFSVLSR HLPNLQMHKE 60
NPVLDIVSNP EQSAVEQGDS NSSFNEHLKE KKASDPVESS HLGTSGSISQ VIERLPQPNR 120
TSSALAVTVE AASLPEEEKE EEELEEEKEG VGANAPGADS LAAEDSASSQ LGFGVLELSQ 180
SQDVEEHTVP YDVNQEHLQL VTTNSGSSPL SDVDASTAIK CEEQPTEDIA MIEQPSKDIP 240
VTVQPGKGIH VVEEQNLPLV RSEDRPSSPQ VSVAAVETKE QVPARELLEE GPQVQPSSEP 300
EVSSTQEDLF DQSSKTASDG CSTPSREEGG CSPVSTPATT LQLLQLSGQK PLVQESLSTN 360
SSDLVAPSPD AFRSTPFIVP SSPTEQGGRK DEPMDMSVIP VGGEPFQKLH DDEAMETEKP 420
LLPSQPAVSP QASTPVSRST PVFTPGSLPI PSQPEFSHDI FIPSPSLEEP SDDVKKGGGL 480
HSSSLTVECS KTSESEPKNF TDDLGLSMTG DSCKLMLSTS EYSQSSKMES LGSPRTEEDR 540
ENTQIDDTEP LSPVSNSKLP ADSENVLVTP SQDDQVEMSQ NVDKAKEDET EDRGDCKGRE 600
DAVAEDVCID LTCDSGSQAV PSPATRSEAL SSVLDQEEAM DTKEHHPEEG FSGSEVEEVP 660
ETPCGSHREE PKEEPMESIP LHLSLTETQS EALCLQKEAP KEECPEAMEV ETSVISIDSP 720
QKLQVLDQEL EHKDPDTWEE ATSEDSSVVI VDVKEPSPRA DVSCEPLEEV EKCSDSQSWE 780
GVAPEEEPCA ENRLDTPEEK RIECDGDSKA ETTEKDAVTE DSPQPPLPSV RDEPVRPDQE 840
TQQPQVQEKE SPVTVDAEVA DDKQLGPEGA CQQLEKAPAC ASQSFCESSS ETPFHFTLPK 900
EGDIIPPLTG ATPPLIGHLK LEPKRHSTPI GISNYPESTI ATSDVTSESM VEINDPLLGN 960
EKGDSESAPE MDGKLSLKMK LVSPETEASE ESLQFSLEKP TTAERKNGST AIAEPVASLQ 1020
KPVPVFGCIY EAQQEKEAQS EAPPSAPDRA NLLHFPSAQE EDKERPDVTP KLRQSEQPVK 1080
PVGPVMDDAA PEDSASPVSQ QRASQEQRAS QEPFSPAEDV METDLLEGLA ANQDRPSKML 1140
MDRPTQSNIG IQTVDHSLCA PETVSAATQT VKSVCEQGTS TAEQNSGKQD ATVQTERGSG 1200
EKPASAPVDD TESLHSQGEE EFEMPQPPHG HVLHRHMRTI REVRTLVTRV ITDVYYVDGT 1260
EVERKVTEET EEPIVECQEC ETEVSPSQTG GSSGDLGDIS SFSSKASSSH HTSSGTSLSA 1320
IHSSGSSGRG AGPLKGKASG TEAADFALPS SRGGPGKLRE TVVSGPLGVE DISPSMSPDD 1380
KSFTRIMPRV PDSTKRTDAS SSTLRRSDSP EIPFQAATGS SDGLDSSSSG NSFVGLRVVA 1440
KWSSNGYFYS GKITRDVGAG KYKLLFDDGY ECDVLGKDIL LCDPIPLDTE VTALSEDEYF 1500
SAGVVKGHRK ESGELYYSIE KEGQRKWYKR MAVILSLEQG NRLREQYGLG PYEAVTPLTK 1560
AADISLDNLV EGKRKRRSNI SSPVTPTAAS SSSTTPTRKA TESPRASTGV PSGKRKLPTS 1620
EEERSPAKRG RKSATVKPGT VGAAEFVSPC ETGDNIGEPS VLEEPRGPLP LNKTLFLGYA 1680
FLLTMATTSD KLASRSKLLD GPTGSSEEEE EFLEIPPFNK QYTECQLRAG AGYILEDFNE 1740
AQCNTAYQCL LIADQHCRTR KYFLCLASGI PCVSHVWVHD SCHANQLQNY RNYLLPAGYS 1800
LEEQRILDWQ PRENPFQNLK VLLVSDQQQN FLELWSEILM TGGAASVKQH HSSAHNKDIA 1860
LGVFDVVVTD PSCPASVLKC AEALQLPVVS QEWVIQCLIV GERIGFKQHP KYKHDYVSH 1919 
Gene Ontology
 GO:0000776; C:kinetochore; IDA:MGI.
 GO:0005657; C:replication fork; IDA:MGI.
 GO:0003684; F:damaged DNA binding; IDA:MGI.
 GO:0042162; F:telomeric DNA binding; IDA:MGI.
 GO:0008134; F:transcription factor binding; TAS:MGI.
 GO:0006281; P:DNA repair; IDA:MGI.
 GO:0006355; P:regulation of transcription, DNA-dependent; TAS:MGI. 
Interpro
 IPR015125; 53-BP1_Tudor.
 IPR001357; BRCT_dom.
 IPR014722; Rib_L2_dom2. 
Pfam
 PF09038; 53-BP1_Tudor 
SMART
 SM00292; BRCT 
PROSITE
 PS50172; BRCT 
PRINTS