CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043679
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 
Protein Synonyms/Alias
  
Gene Name
 SMARCAL1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
139KNYDPDTKTWNFSMNubiquitination[1]
314GVNFAIAKGGRLLLAubiquitination[1, 2, 3]
489AVMLRRLKSDVLSQLubiquitination[1]
693PLIQEKIKVLAEAGLubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 796 AA 
Protein Sequence
QLLSYELGQG HAQASPEIRF TPFANPTHKP LAKPKSSQET PAHSSGQPPR DAKLEAKTAK 60
ASPSGQNISY IHSSSESVTP RTEGRLQQKS GSSVQKGVNS QKGKCVRNGD RFQVLIGYNA 120
ELIAVFKTLP SKNYDPDTKT WNFSMNDYSA LMKAAQSLPT VNLQPLEWAY GSSESPSTSS 180
EGQAGLPSAP SLSFVKGRCM LISRAYFEAD ISYSQDLIAL FKQMDSRRYD VKTRKWSFLL 240
EEHSKLIAKV RCLPQVQLDP LPTTLTLAFA SQLKKTSLSL TPDVPEADLS EVDPKLVSNL 300
MPFQRAGVNF AIAKGGRLLL ADDMGLGKTI QAICIAAFYR KEWPLLVVVP SSVRFTWEQA 360
FLRWLPSLSP DCINVVVTGK DRLTAGLINI VSFDLLSKLE KQLKTPFKVV IIVAKRVILL 420
SGTPAMSRPA ELYTQIIAVK PTFFPQFHAF GLRYCDAKRM PWGWDYSGSS NLGELKLLLE 480
EAVMLRRLKS DVLSQLPAKQ RKIVVIAPGR INARTRAALD AAAKEMTTKD KTKQQQKDAL 540
ILFFNRTAEA KIPSVIEYIL DLLESGREKF LVFAHHKVVL DAITQELERK HVQHIRIDGS 600
TSSAEREDLC QQFQLSERHA VAVLSITAAN MGLTFSSADL VVFAELFWNP GVLIQAEDRV 660
HRIGQTSSVG IHYLVAKGTA DDYLWPLIQE KIKVLAEAGL SETNFSEMTE STDYLYKDPK 720
QQKIYDLFQK SFEKEGSDME LLEAAESFDP GSASGTSGSS SQNMGDTLDE SSLTASPQKK 780
RRFEFFDNWD SFTSPL 796 
Gene Ontology
 GO:0005634; C:nucleus; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0004386; F:helicase activity; IEA:InterPro.
 GO:0016568; P:chromatin modification; IEA:InterPro. 
Interpro
 IPR010003; HARP_dom.
 IPR014001; Helicase_ATP-bd.
 IPR001650; Helicase_C.
 IPR027417; P-loop_NTPase.
 IPR000330; SNF2_N. 
Pfam
 PF07443; HARP
 PF00271; Helicase_C
 PF00176; SNF2_N 
SMART
 SM00487; DEXDc
 SM00490; HELICc 
PROSITE
 PS51467; HARP
 PS51192; HELICASE_ATP_BIND_1
 PS51194; HELICASE_CTER 
PRINTS