CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010145
UniProt Accession
Genbank Protein ID
 U00089 
Genbank Nucleotide ID
Protein Name
 Ribonuclease R 
Protein Synonyms/Alias
 RNase R; VacB protein homolog 
Gene Name
 rnr 
Gene Synonyms/Alias
 vacB; MPN_243; MP589 
Created Date
 July 27, 2013 
Organism
 Mycoplasma pneumoniae (strain ATCC 29342 / M129) 
NCBI Taxa ID
 272634 
Lysine Modification
Position
Peptide
Type
References
687EDFFVFEKDRMVLRGacetylation[1]
Reference
 [1] Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium.
 van Noort V, Seebacher J, Bader S, Mohammed S, Vonkova I, Betts MJ, Kühner S, Kumar R, Maier T, O'Flaherty M, Rybin V, Schmeisky A, Yus E, Stülke J, Serrano L, Russell RB, Heck AJ, Bork P, Gavin AC.
 Mol Syst Biol. 2012 Feb 28;8:571. [PMID: 22373819] 
Functional Description
 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity). 
Sequence Annotation
 DOMAIN 645 726 S1 motif.  
Keyword
 Complete proteome; Cytoplasm; Exonuclease; Hydrolase; Nuclease; Reference proteome; RNA-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 726 AA 
Protein Sequence
MKVLTDLQKR IFAIVKKENG KPIPPGIVVR MMENQAGFPG KQQVYRAIDD LLEWHIFRKS 60
GGATNQLLIN YELADPVLDQ KFQGILNLGN KNTGFVRPLD DDKTVYYIHF SNLAGALDGD 120
LVEFCPLDKP QVGDKFDAAV LKIVKRSRVL YAGNFLIEYS DFGQEFRIVA DNPRFYLTPI 180
VNKASVPAEL ESNTKVAFQI DEYDPANNLC KVSIQQILGN NDEPLINLKA IMLDHSIVFE 240
DNDVVEQQAA KLQFDEKEQS KPYRKDLTEL AFVTIDPATS KDLDDAIYVK RTDKGFVLYV 300
AIADVAYYVQ RNSELDIEAR HKTSSIYLPG YYVVPMLPER LSNELCSLNP NEKRYVVVCE 360
LNFDHEARLN FSEVYPATIV SQRRFAYSEV NDWLEDSDAL KDESATVLES LKAGFTLSEL 420
IAEQRKKKGT IDLSHSETEV VVDQNYYPIE IRFLTHGKAE TMIENLMVVA NEAVAWTLTN 480
HKVHLPYRVH PRPSKKKLQM LLENIVELKI TQPNFVLDTV TSTQIAAWLK ENKDNPSYDI 540
FVILLLRTLG KAFYIVNPLI HFSIGSHHYT HFTSPIRRYA DLTVHRLLWM NLFTPERFTD 600
TEREQLNAEL EQICETINDT EIKINGCERT ANDYLTTLYL SKQVGQTFHG FISAITSFGI 660
FMRMDENNFD GLIKITSIPE DFFVFEKDRM VLRGKRTNKV FRIGDRLTAK LTEIDTVQKR 720
AILTLV 726 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0008859; F:exoribonuclease II activity; IEA:HAMAP.
 GO:0003723; F:RNA binding; IEA:HAMAP.
 GO:0090305; P:nucleic acid phosphodiester bond hydrolysis; IEA:GOC.
 GO:0016070; P:RNA metabolic process; IEA:HAMAP. 
Interpro
 IPR011129; Cold_shock_prot.
 IPR012340; NA-bd_OB-fold.
 IPR003029; Rbsml_prot_S1_RNA-bd_dom.
 IPR022967; RNA-binding_domain_S1.
 IPR001900; RNase_II/R.
 IPR022966; RNase_II/R_CS.
 IPR004476; RNase_II/RNase_R.
 IPR011805; RNase_R. 
Pfam
 PF00773; RNB
 PF00575; S1 
SMART
 SM00357; CSP
 SM00955; RNB
 SM00316; S1 
PROSITE
 PS01175; RIBONUCLEASE_II
 PS50126; S1 
PRINTS