CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023335
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Host cell factor 
Protein Synonyms/Alias
 dHcf; HCF N-terminal chain; HCF C-terminal chain 
Gene Name
 Hcf 
Gene Synonyms/Alias
 CG1710 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
688TTTSIGGKQYFIQKPacetylation[1]
780PHTMAGGKLIMKNSNacetylation[1]
802TPNVMGGKPAFVITNacetylation[1]
881ISNQSGVKMLRNISSacetylation[1]
957TTALSARKSFVFNAGacetylation[1]
975RTVTLATKSINAKSIacetylation[1]
980ATKSINAKSIPQSQPacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 May be involved in control of cell cycle. 
Sequence Annotation
 REPEAT 85 133 Kelch 1.
 REPEAT 135 181 Kelch 2.
 REPEAT 189 237 Kelch 3.
 REPEAT 259 307 Kelch 4.
 REPEAT 308 373 Kelch 5.
 MOTIF 1470 1495 Bipartite nuclear localization signal.
 MOD_RES 477 477 Phosphoserine.
 MOD_RES 958 958 Phosphoserine.
 MOD_RES 966 966 Phosphoserine.
 MOD_RES 1126 1126 Phosphothreonine.
 MOD_RES 1489 1489 Phosphoserine.  
Keyword
 Alternative splicing; Autocatalytic cleavage; Cell cycle; Complete proteome; Kelch repeat; Nucleus; Phosphoprotein; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1500 AA 
Protein Sequence
MEGSDFVDPA FSSGERISAS DLNSEHIIQA ENHSFANRIS MDMDVPDGHQ LDSNLTGFRW 60
KRVLNPTGPQ PRPRHGHRAI NIKELMVVFG GGNEGIVDEL HVYNTVTNQW YVPVLKGDVP 120
NGCAAYGFVV EGTRMFVFGG MIEYGKYSNE LYELQATKWE WRKMYPESPD SGLSPCPRLG 180
HSFTMVGEKI FLFGGLANES DDPKNNIPKY LNDLYILDTR GVHSHNGKWI VPKTYGDSPP 240
PRESHTGISF ATKSNGNLNL LIYGGMSGCR LGDLWLLETD SMTWSKPKTS GEAPLPRSLH 300
SSTMIGNKMY VFGGWVPLVI NDSKSTTERE WKCTNTLAVL DLETMTWENV TLDTVEENVP 360
RARAGHCAVG IQSRLYVWSG RDGYRKAWNN QVCCKDLWYL EVSKPLYAVK VALVRASTHA 420
LELSWTATTF AAAYVLQIQK IEQPLNTSSK LLSNNIVQQG TPTSAETSGI NISANRSGSA 480
LGLGVEATST VLKLEKESLQ LSGCQPETNV QPSVNDLLQS MSQPSSPASR ADKDPLSSGG 540
GTTFNLSTSV ASVHPQISVI SSTAAVTGND TASPSGAINS ILQKFRPVVT AVRTSTTTAV 600
SIATSTSDPL SVRVPSTMSA NVVLSSSSST LRIVPSVTAS HSLRIASSQA SGNNCRSSSA 660
INILKTALPN VAVQSQPTSS TTTSIGGKQY FIQKPLTLAP NVQLQFVKTS GGMTVQTLPK 720
VNFTASKGTP PHGISIANPH LASGITQIQG STVPGSQIQK PIVSGNVLKL VSPHTMAGGK 780
LIMKNSNILQ MGKVTPNVMG GKPAFVITNK QGTPLGNQQI IIVTTGGNVR SVPTSTVMTS 840
AGGSASGTNI VSIVNSTSTT PSPLQALSGQ KTLISNQSGV KMLRNISSVQ ASSSMAFGQK 900
QSGTPIHQKT ALYIGGKAVT VMSTNTSMAA SGNKVMVLPG TSSNNSPATT TALSARKSFV 960
FNAGGSPRTV TLATKSINAK SIPQSQPVTE TNNHSVATIK DTDPMDDIIE QLDGAGDLLK 1020
LSESEGQHGS EENENNGENA TSSSASALFT GGDTAGPSRA QNPIVMEHPV DIIEDVSGVS 1080
STTDVNETAI VSGDTIESLK MSEKENDDVK SMGEKSILSD DCHQPTTSET EAATILTTIK 1140
SAEALVLETA EIRKDHTGCT IGSLKENQDE NKKFKQRQES SPSQNIHQFQ NVDGSQLEAL 1200
ASAALLQAAT SDTTALALKE LIERPESETN TRSSNIAEIQ QNNVQSTLAV VVPNTSQNEN 1260
QKWHTVGVFK DLSHTVTSYI DSNCISDSFF DGIDVDNLPD FSKFPRTNLE PGTAYRFRLS 1320
AINSCGRGEW GEISSFKTCL PGFPGAPSAI KISKDVKEGA HLTWEPPPAQ KTKEIIEYSV 1380
YLAVKPTAKD KALSTPQLAF VRVYVGAANQ CTVPNASLSN AHVDCSNKPA IIFRIAARNQ 1440
KGYGPATQVR WLQDPAAAKQ HTPTVTPNLK RGPEKSTIGS SNIANTFCSP HKRGRNGLHD 1500 
Gene Ontology
 GO:0000123; C:histone acetyltransferase complex; IDA:FlyBase.
 GO:0044666; C:MLL3/4 complex; IDA:FlyBase.
 GO:0048188; C:Set1C/COMPASS complex; IDA:FlyBase.
 GO:0003682; F:chromatin binding; IDA:FlyBase.
 GO:0003713; F:transcription coactivator activity; TAS:UniProtKB.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0006338; P:chromatin remodeling; IDA:FlyBase.
 GO:0043966; P:histone H3 acetylation; IDA:FlyBase.
 GO:0051568; P:histone H3-K4 methylation; IC:FlyBase.
 GO:0043967; P:histone H4 acetylation; IDA:FlyBase.
 GO:0045927; P:positive regulation of growth; IGI:FlyBase.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:FlyBase. 
Interpro
 IPR003961; Fibronectin_type3.
 IPR015916; Gal_Oxidase_b-propeller.
 IPR013783; Ig-like_fold.
 IPR015915; Kelch-typ_b-propeller.
 IPR006652; Kelch_1. 
Pfam
 PF01344; Kelch_1 
SMART
 SM00060; FN3 
PROSITE
  
PRINTS