CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018436
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 S-adenosylmethionine decarboxylase proenzyme 
Protein Synonyms/Alias
 AdoMetDC; SAMDC; S-adenosylmethionine decarboxylase beta chain; S-adenosylmethionine decarboxylase alpha chain 
Gene Name
 speD 
Gene Synonyms/Alias
 STM0165 
Created Date
 July 27, 2013 
Organism
 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 
NCBI Taxa ID
 99287 
Lysine Modification
Position
Peptide
Type
References
14HGFNNLTKSLSFCIYacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity). 
Sequence Annotation
 ACT_SITE 112 112 Schiff-base intermediate with substrate;
 ACT_SITE 117 117 Proton acceptor; for processing activity
 ACT_SITE 140 140 Proton donor; for catalytic activity (By
 MOD_RES 112 112 Pyruvic acid (Ser); by autocatalysis (By  
Keyword
 Autocatalytic cleavage; Complete proteome; Decarboxylase; Lyase; Polyamine biosynthesis; Pyruvate; Reference proteome; S-adenosyl-L-methionine; Schiff base; Spermidine biosynthesis; Zymogen. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 264 AA 
Protein Sequence
MKKLKLHGFN NLTKSLSFCI YDICYAKTAE ERDGYIAYID ELYNANRLTE ILSETCSIIG 60
ANILNIARQD YEPQGASVTI LVSEEPIDPK LIDQTEHPGP LPETVVAHLD KSHICVHTYP 120
ESHPEGGLCT FRADIEVSTC GVISPLKALN YLIHQLESDI VTIDYRVRGF TRDVNGMKHF 180
IDHEINSIQN FMSEDMKSLY DMVDVNVYQE NIFHTKMLLK EFDLKHYMFH TKPEDLTETE 240
RQEITAALWK EMREIYYGRN ISAV 264 
Gene Ontology
 GO:0004014; F:adenosylmethionine decarboxylase activity; IEA:HAMAP.
 GO:0006557; P:S-adenosylmethioninamine biosynthetic process; IEA:HAMAP.
 GO:0008295; P:spermidine biosynthetic process; IEA:HAMAP. 
Interpro
 IPR003826; AdoMetDC_fam_prok.
 IPR009165; S-AdoMet_deCO2ase_bac.
 IPR016067; S-AdoMet_deCO2ase_core. 
Pfam
 PF02675; AdoMet_dc 
SMART
  
PROSITE
  
PRINTS