UniProt Accession

 B4DN24_HUMAN; B4DN24 

Genbank Protein ID

 AC007250; AK297736 

Genbank Nucleotide ID

 BAG60086.1 

Protein Name

 E3 ubiquitin-protein ligase FANCL 

Protein Synonyms/Alias

 cDNA FLJ51649, highly similar to Ubiquitin ligase protein FANCL (EC 6.3.2.-) 

Gene Name

 FANCL 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
22	LLPQNRSKTVYEGFI	ubiquitination	[1, 2]
49	LPEDLQLKNARLLCS	ubiquitination	[1, 2, 3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Ligase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 127 AA 

Protein Sequence

Gene Ontology

 GO:0043240; C:Fanconi anaemia nuclear complex; IEA:InterPro.
 GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro.
 GO:0006281; P:DNA repair; IEA:InterPro.
 GO:0016567; P:protein ubiquitination; IEA:GOC. 

Interpro

 IPR026848; Fancl.
 IPR019162; FancL_WD-rpt_cont_dom. 

Pfam

 PF09765; WD-3 

SMART

  

PROSITE

  

PRINTS