CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008431
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Vesicle-associated membrane protein 7 
Protein Synonyms/Alias
 VAMP-7; Synaptobrevin-like protein 1; Tetanus-insensitive VAMP; Ti-VAMP 
Gene Name
 VAMP7 
Gene Synonyms/Alias
 SYBL1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
84SENKGLDKVMETQAQubiquitination[1]
96QAQVDELKGIMVRNIubiquitination[1]
119RLELLIDKTENLVDSubiquitination[1]
131VDSSVTFKTTSRNLAubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation. 
Sequence Annotation
 DOMAIN 7 110 Longin.
 DOMAIN 125 185 v-SNARE coiled-coil homology.
 MOD_RES 2 2 N-acetylalanine; partial.  
Keyword
 3D-structure; Acetylation; Alternative splicing; Cell junction; Coiled coil; Complete proteome; Cytoplasmic vesicle; Direct protein sequencing; Endoplasmic reticulum; Endosome; Exocytosis; Golgi apparatus; Lysosome; Membrane; Protein transport; Reference proteome; Signal-anchor; Synapse; Synaptosome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 220 AA 
Protein Sequence
MAILFAVVAR GTTILAKHAW CGGNFLEDFE RSRAFNFLNE IKKRFQTTYG SRAQTALPYA 60
MNSEFSSVLA AQLKHHSENK GLDKVMETQA QVDELKGIMV RNIDLVAQRG ERLELLIDKT 120
ENLVDSSVTF KTTSRNLARA MCMKNLKLTI IIIIVSIVFI YIIVSPLCGG FTWPSCVKK 179 
Gene Ontology
 GO:0045177; C:apical part of cell; IEA:Compara.
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
 GO:0005794; C:Golgi apparatus; IDA:HPA.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0031902; C:late endosome membrane; ISS:UniProtKB.
 GO:0005765; C:lysosomal membrane; ISS:UniProtKB.
 GO:0043005; C:neuron projection; ISS:UniProtKB.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0045335; C:phagocytic vesicle; ISS:UniProtKB.
 GO:0030670; C:phagocytic vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0031201; C:SNARE complex; ISS:UniProtKB.
 GO:0045202; C:synapse; IEA:UniProtKB-KW.
 GO:0030658; C:transport vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0017156; P:calcium ion-dependent exocytosis; ISS:UniProtKB.
 GO:0008333; P:endosome to lysosome transport; IDA:UniProtKB.
 GO:0043308; P:eosinophil degranulation; ISS:UniProtKB.
 GO:0006888; P:ER to Golgi vesicle-mediated transport; ISS:UniProtKB.
 GO:0043001; P:Golgi to plasma membrane protein transport; IEA:Compara.
 GO:0043312; P:neutrophil degranulation; ISS:UniProtKB.
 GO:0006911; P:phagocytosis, engulfment; ISS:UniProtKB.
 GO:0006892; P:post-Golgi vesicle-mediated transport; TAS:Reactome.
 GO:1900483; P:regulation of protein targeting to vacuolar membrane; IEA:Compara.
 GO:0034197; P:triglyceride transport; IEA:Compara.
 GO:0006906; P:vesicle fusion; IDA:UniProtKB.
 GO:0048280; P:vesicle fusion with Golgi apparatus; IEA:Compara. 
Interpro
 IPR011012; Longin-like_dom.
 IPR010908; Longin_dom.
 IPR001388; Synaptobrevin. 
Pfam
 PF13774; Longin
 PF00957; Synaptobrevin 
SMART
  
PROSITE
 PS50859; LONGIN
 PS00417; SYNAPTOBREVIN
 PS50892; V_SNARE 
PRINTS
 PR00219; SYNAPTOBREVN.