| Tag | Content |
|---|
| CPLM ID | CPLM-035851 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Inosine-5'-monophosphate dehydrogenase |
Protein Synonyms/Alias | IMP dehydrogenase; IMPD; IMPDH |
Gene Name | guaB |
Gene Synonyms/Alias | EAM_2465 |
Created Date | July 27, 2013 |
Organism | Erwinia amylovora (strain ATCC 49946 / CCPPB 0273 / Ea273 / 27-3) |
NCBI Taxa ID | 716540 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 203 | ITVKDFQKAERKPLA | acetylation | [1] |
|
Reference | [1] Differential lysine acetylation profiles of Erwinia amylovora strains revealed by proteomics. Wu X, Vellaichamy A, Wang D, Zamdborg L, Kelleher NL, Huber SC, Zhao Y. J Proteomics. 2013 Feb 21;79:60-71. [ PMID: 23234799] |
Functional Description | Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity). |
Sequence Annotation | DOMAIN 93 149 CBS 1 (By similarity).
DOMAIN 153 214 CBS 2 (By similarity).
NP_BIND 248 250 NAD (By similarity).
NP_BIND 298 300 NAD (By similarity).
REGION 338 340 IMP binding (By similarity).
REGION 361 362 IMP binding (By similarity).
REGION 385 389 IMP binding (By similarity).
ACT_SITE 305 305 Thioimidate intermediate (By similarity).
METAL 300 300 Potassium; via carbonyl oxygen (By
METAL 302 302 Potassium; via carbonyl oxygen (By
METAL 305 305 Potassium; via carbonyl oxygen (By
METAL 469 469 Potassium; via carbonyl oxygen; shared
METAL 470 470 Potassium; via carbonyl oxygen; shared
METAL 471 471 Potassium; via carbonyl oxygen; shared
BINDING 303 303 IMP (By similarity).
BINDING 415 415 IMP (By similarity). |
Keyword | CBS domain; Complete proteome; GMP biosynthesis; Metal-binding; NAD; Oxidoreductase; Potassium; Purine biosynthesis; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 488 AA |
Protein Sequence | MLRITKEALT FDDVLLVPAH STVLPNTADL STQLTKNIRL NIPMLSAAMD TVTEAGLAIA 60
LAQEGGLGFI HKNMSIERQA EEVRRVKKHE SGVVTDPQTV LPTTALSEVK ALTERNGFAG 120
YPVVNGENEL VGIITGRDVR FVTDLSLPVS AVMTPKERLV TVKEGEAREV VLHKMHEKRV 180
EKALVVDDSF HLLGMITVKD FQKAERKPLA CKDEHGRLRV GAAVGAGAGN EERVDALVAA 240
GVDVLLIDSS HGHSEGVLQR IRETRAKYPD LQIVGGNVAT GAGALALAEA GVSAVKVGIG 300
PGSICTTRIV TGVGVPQITA VSDAVAALEG TGIPVIADGG IRFSGDIAKA IAAGAAAVMV 360
GSMLAGTDES PGEIELYQGR SYKSYRGMGS LGAMSKGSSD RYFQTDNAAD KLVPEGIEGR 420
VAYKGRLKEI VHQQMGGLRS CMGLTGCATI DELRTKAQFV RISGAGISES HVHDVTITKE 480
SPNYRMGS 488 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |