| Tag | Content |
|---|
| CPLM ID | CPLM-021762 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | RIMS-binding protein 2 |
Protein Synonyms/Alias | RIM-BP2 |
Gene Name | Rimbp2 |
Gene Synonyms/Alias | Rbp2 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 60 | LLSRDLEKFRQHAGS | ubiquitination | [1] | | 557 | RLRSLEAKAVSVRTL | ubiquitination | [1] |
|
Reference | [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J. J Proteome Res. 2012 Sep 7;11(9):4722-32. [ PMID: 22871113] |
Functional Description | Plays a role in the synaptic transmission as bifunctional linker that interacts simultaneously with RIMS1, RIMS2, CACNA1D and CACNA1B (By similarity). |
Sequence Annotation | DOMAIN 164 231 SH3 1.
DOMAIN 294 374 Fibronectin type-III 1.
DOMAIN 388 460 Fibronectin type-III 2.
DOMAIN 484 570 Fibronectin type-III 3.
DOMAIN 848 916 SH3 2.
DOMAIN 952 1019 SH3 3.
MOD_RES 832 832 Phosphoserine (By similarity).
CROSSLNK 724 724 Glycyl lysine isopeptide (Lys-Gly) |
Keyword | Cell junction; Cell membrane; Complete proteome; Isopeptide bond; Membrane; Phosphoprotein; Reference proteome; Repeat; SH3 domain; Synapse; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1049 AA |
Protein Sequence | MREAAERRQQ LELEHEQALA ILNAKQQEIQ LLQQSKVREL EEKCRVQSEQ FNLLSRDLEK 60
FRQHAGSIDL LGSNSVALLD VPLAPGKPFS QYMNGLATSI HKGHEGPTGH YSVIGDYIPL 120
SGDKLESPCV KPSFLLRSSS PRCRFESEMD DDRSSNKSKH SSSGKVHLCV ARYSYNPFDG 180
PNENPEAELP LTAGKYLYVY GDMDEDGFYE GELLDGQRGL VPSNFVDFIQ DNESRFAGTL 240
GSEQDQNFLN HSGISLERDS ILHLHSPTQV DSGITDNGGG TLDVNIDDIG EDIVPYPRKI 300
TLIKQLAKSV IVGWEPPAVP PGWGTVSSYN VLVDKETRMS LALGRRTKAL IEKLNTAACT 360
YRISVQCVTS RGNSDELQCT LLVGKDVVVA PSQLRVDNIT QISAQLSWLP TNSNYSHIIF 420
LNEEELDIVK AARYKYQFFN LRPNMAYKVK VLAQPHQMPW QLPLEQREKD EACVEFSTLP 480
AGPPAPPQDV TVQAGATTAS VQVSWKPPAL TPTGLSNGAN VTGYGVYAKG QRVAEVIAPT 540
ANGAAVELVR LRSLEAKAVS VRTLSAQGES MDSALAAIPP DLLVPPAPHP RTAPPPKPLT 600
SDMDTKDLGP HVKVDESWEQ SRPPGPAHGH MLEPPDMHST GPGRRSPSPS RILPQPQGAP 660
VSTTVAKAMA REAAQRVAET SKLEKRSLFL EQSSAGPYAN SDEEDGYASP EVKRRGTSVD 720
DFLKGSELGQ QPHCCHGDEY HTESSRGSDL SDIMEEDEEE LYSEMQLEDG GRRRPSGTSH 780
NALKILGNSA LMGRGDRMEH VSRRYSHSGG GPQRHRPMAP SIDEYTGRDH LSPDFYDESE 840
TDPGAEELPA RIFVALFDYD PLTMSPNPDA AEEELPFKEG QIIKVYGDKD ADGFYRGETC 900
ARLGLIPCNM VSEIHADDEE MMDQLLRQGF LPLNTPVEKI ERSRRSGRGH SVPTRRMVAL 960
YDYDPRESSP NVDVEAELLF CTGDIITVFG EIDEDGFYYG ELNGQKGLVP SNFLEEVPDD 1020
VEVHLSDAPP HYSHDPPMRT KAKRVSQPP 1049 |
Gene Ontology | GO:0030054; C:cell junction; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0045202; C:synapse; IEA:UniProtKB-SubCell. GO:0010923; P:negative regulation of phosphatase activity; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |