UniProt Accession

 AEDO_HUMAN; Q96SZ5; B1AL29 

Genbank Protein ID

 AL133417; CH471083; BC018660; BC028589; BC067740; AK027453 

Genbank Nucleotide ID

 CAH73826.2; EAW54235.1; AAH18660.3; AAH28589.2; AAH67740.2; BAB55123.1 

Protein Name

 2-aminoethanethiol dioxygenase 

Protein Synonyms/Alias

 Cysteamine dioxygenase 

Gene Name

 ADO 

Gene Synonyms/Alias

 C10orf22 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
55	PENLSKLKSLLTQLR	ubiquitination	[1, 2, 3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Dioxygenase; Iron; Metal-binding; Oxidoreductase; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 270 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0047800; F:cysteamine dioxygenase activity; IEA:EC.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. 

Interpro

 IPR012864; Cysteamine_dioxygenase.
 IPR014710; RmlC-like_jellyroll.
 IPR011051; RmlC_Cupin. 

Pfam

 PF07847; DUF1637 

SMART

  

PROSITE

  

PRINTS