Tag | Content |
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CPLM ID | CPLM-019165 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | SLAM family member 6 |
Protein Synonyms/Alias | Activating NK receptor; NK-T-B-antigen; NTB-A; CD352 |
Gene Name | SLAMF6 |
Gene Synonyms/Alias | KALI; UNQ6123/PRO20080 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
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319 | INHSKESKPTFSRAT | ubiquitination | [1] |
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Reference | [1] Integrated proteomic analysis of post-translational modifications by serial enrichment. Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA. Nat Methods. 2013 Jul;10(7):634-7. [ PMID: 23749302] |
Functional Description | Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. |
Sequence Annotation | DOMAIN 132 209 Ig-like. MOD_RES 274 274 Phosphotyrosine. MOD_RES 278 278 Phosphoserine. MOD_RES 309 309 Phosphotyrosine. CARBOHYD 58 58 N-linked (GlcNAc...) (Potential). CARBOHYD 87 87 N-linked (GlcNAc...) (Potential). CARBOHYD 137 137 N-linked (GlcNAc...) (Potential). CARBOHYD 144 144 N-linked (GlcNAc...) (Potential). CARBOHYD 161 161 N-linked (GlcNAc...) (Potential). CARBOHYD 171 171 N-linked (GlcNAc...); atypical. CARBOHYD 178 178 N-linked (GlcNAc...). CARBOHYD 203 203 N-linked (GlcNAc...) (Potential). DISULFID 147 214 DISULFID 153 195 |
Keyword | 3D-structure; Alternative splicing; Cell membrane; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Phosphoprotein; Receptor; Reference proteome; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 332 AA |
Protein Sequence | MLWLFQSLLF VFCFGPGNVV SQSSLTPLMV NGILGESVTL PLEFPAGEKV NFITWLFNET 60 SLAFIVPHET KSPEIHVTNP KQGKRLNFTQ SYSLQLSNLK MEDTGSYRAQ ISTKTSAKLS 120 SYTLRILRQL RNIQVTNHSQ LFQNMTCELH LTCSVEDADD NVSFRWEALG NTLSSQPNLT 180 VSWDPRISSE QDYTCIAENA VSNLSFSVSA QKLCEDVKIQ YTDTKMILFM VSGICIVFGF 240 IILLLLVLRK RRDSLSLSTQ RTQGPAESAR NLEYVSVSPT NNTVYASVTH SNRETEIWTP 300 RENDTITIYS TINHSKESKP TFSRATALDN VV 332 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0004872; F:receptor activity; IEA:InterPro. |
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Pfam | |
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PRINTS | |