CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019165
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 SLAM family member 6 
Protein Synonyms/Alias
 Activating NK receptor; NK-T-B-antigen; NTB-A; CD352 
Gene Name
 SLAMF6 
Gene Synonyms/Alias
 KALI; UNQ6123/PRO20080 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
319INHSKESKPTFSRATubiquitination[1]
Reference
 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
 Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. 
Sequence Annotation
 DOMAIN 132 209 Ig-like.
 MOD_RES 274 274 Phosphotyrosine.
 MOD_RES 278 278 Phosphoserine.
 MOD_RES 309 309 Phosphotyrosine.
 CARBOHYD 58 58 N-linked (GlcNAc...) (Potential).
 CARBOHYD 87 87 N-linked (GlcNAc...) (Potential).
 CARBOHYD 137 137 N-linked (GlcNAc...) (Potential).
 CARBOHYD 144 144 N-linked (GlcNAc...) (Potential).
 CARBOHYD 161 161 N-linked (GlcNAc...) (Potential).
 CARBOHYD 171 171 N-linked (GlcNAc...); atypical.
 CARBOHYD 178 178 N-linked (GlcNAc...).
 CARBOHYD 203 203 N-linked (GlcNAc...) (Potential).
 DISULFID 147 214
 DISULFID 153 195  
Keyword
 3D-structure; Alternative splicing; Cell membrane; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Phosphoprotein; Receptor; Reference proteome; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 332 AA 
Protein Sequence
MLWLFQSLLF VFCFGPGNVV SQSSLTPLMV NGILGESVTL PLEFPAGEKV NFITWLFNET 60
SLAFIVPHET KSPEIHVTNP KQGKRLNFTQ SYSLQLSNLK MEDTGSYRAQ ISTKTSAKLS 120
SYTLRILRQL RNIQVTNHSQ LFQNMTCELH LTCSVEDADD NVSFRWEALG NTLSSQPNLT 180
VSWDPRISSE QDYTCIAENA VSNLSFSVSA QKLCEDVKIQ YTDTKMILFM VSGICIVFGF 240
IILLLLVLRK RRDSLSLSTQ RTQGPAESAR NLEYVSVSPT NNTVYASVTH SNRETEIWTP 300
RENDTITIYS TINHSKESKP TFSRATALDN VV 332 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0004872; F:receptor activity; IEA:InterPro. 
Interpro
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003599; Ig_sub.
 IPR013106; Ig_V-set.
 IPR015631; SLAM_fam_rcpts. 
Pfam
 PF07686; V-set 
SMART
 SM00409; IG 
PROSITE
 PS50835; IG_LIKE 
PRINTS