UniProt Accession

 JPH1_MOUSE; Q9ET80; Q0VB08; Q9EQZ3 

Genbank Protein ID

 AB024445; AB024446; BC120839; BC137669 

Genbank Nucleotide ID

 BAB12043.1; BAB20319.1; AAI20840.1; AAI37670.1 

Protein Name

 Junctophilin-1 

Protein Synonyms/Alias

 JP-1; Junctophilin type 1 

Gene Name

 Jph1 

Gene Synonyms/Alias

 Jp1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
91	GEWSHGFKGRYGVRQ	ubiquitination	[1]
222	GSLLGSMKLRKSESK	ubiquitination	[1]
387	RTAHARAKADAADQA	ubiquitination	[1]
425	QPGPDYIKQRCQEGG	ubiquitination	[1]
499	GARLSQDKQSLAEEQ	ubiquitination	[1]
522	SMSKAPAKELGASVS	ubiquitination	[1]
530	ELGASVSKYSGRHHV	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes. 

Sequence Annotation

 REPEAT 14 36 MORN 1.
 REPEAT 38 59 MORN 2.
 REPEAT 60 82 MORN 3.
 REPEAT 106 128 MORN 4.
 REPEAT 129 151 MORN 5.
 REPEAT 281 303 MORN 6.
 REPEAT 304 326 MORN 7.
 MOD_RES 157 157 Phosphoserine (By similarity).
 MOD_RES 216 216 Phosphoserine.
 MOD_RES 220 220 Phosphoserine (By similarity).
 MOD_RES 448 448 Phosphoserine.
 MOD_RES 452 452 Phosphoserine.
 MOD_RES 461 461 Phosphothreonine (By similarity).
 MOD_RES 465 465 Phosphoserine (By similarity).
 MOD_RES 469 469 Phosphoserine (By similarity).
 MOD_RES 475 475 Phosphoserine (By similarity).  

Keyword

 Cell membrane; Complete proteome; Endoplasmic reticulum; Membrane; Phosphoprotein; Reference proteome; Repeat; Sarcoplasmic reticulum; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 660 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0030314; C:junctional membrane complex; IDA:UniProtKB.
 GO:0014701; C:junctional sarcoplasmic reticulum membrane; IDA:UniProtKB.
 GO:0005886; C:plasma membrane; IDA:UniProtKB.
 GO:0030018; C:Z disc; IDA:MGI.
 GO:0008307; F:structural constituent of muscle; IMP:UniProtKB.
 GO:0007517; P:muscle organ development; IMP:MGI. 

Interpro

 IPR017191; Junctophilin.
 IPR003409; MORN. 

Pfam

 PF02493; MORN 

SMART

 SM00698; MORN 

PROSITE

  

PRINTS