CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011717
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger protein GLI2 
Protein Synonyms/Alias
 Tax helper protein 
Gene Name
 Gli2 
Gene Synonyms/Alias
 Thp 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
630CLHIKAIKTESSGLCsumoylation[1]
716VHRFEQLKREKLKSLsumoylation[1]
Reference
 [1] Small ubiquitin-like Modifier (SUMO) modification inhibits GLI2 protein transcriptional activity in vitro and in vivo.
 Han L, Pan Y, Wang B.
 J Biol Chem. 2012 Jun 8;287(24):20483-9. [PMID: 22549777] 
Functional Description
 Acts as a transcriptional activator. May play a role during embryogenesis. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the TRE-2S regulatory element. Is involved in the smoothened (SHH) signaling pathway. 
Sequence Annotation
 ZN_FING 417 444 C2H2-type 1.
 ZN_FING 455 477 C2H2-type 2; degenerate.
 ZN_FING 483 507 C2H2-type 3.
 ZN_FING 513 538 C2H2-type 4.
 ZN_FING 544 569 C2H2-type 5.
 MOD_RES 145 145 Phosphoserine (By similarity).
 MOD_RES 230 230 Phosphoserine (By similarity).
 MOD_RES 232 232 Phosphoserine (By similarity).
 MOD_RES 238 238 Phosphoserine (By similarity).
 MOD_RES 385 385 Phosphoserine; by DYRK2 (By similarity).
 MOD_RES 707 707 Phosphoserine.
 MOD_RES 708 708 Phosphothreonine.
 MOD_RES 997 997 Phosphoserine; by DYRK2 (By similarity).  
Keyword
 Activator; Complete proteome; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1544 AA 
Protein Sequence
METSAPAPAL EKKEAKSGLL EDSSFPDPGK KACPLAVAAA VAAHGVPQQL LPAFHAPLPI 60
DMRHQEGRYH YDPHSVHSVH GPPTLSGSPV ISDISLIRLS PHPAGPGESP FSAHHPYVNP 120
HMEHYLRSVH SSPTLSMISA ARGLSPADVA HEHLKERGLF SLAAPGTNPS DYYHQMTLMA 180
SHPTPYGDLL MQSGGAASAP HLHDYLNPVD ASRFSSPRVT PRLSRKRALS ISPLSDASLD 240
LQRMIRTSPN SLVAYINNSR SSSAASGSYG HLSAGALSPA FTFPHPINPV AYQQILSQQR 300
GLGSAFGHTP PLIQPSPTFL AQQPMTLTSI STMPTQLSSS SSNCLNDANQ NKQNSESAVS 360
STVNPITIHK RSKVKTEAEG LRPASPLGLT QEQLADLKED LDRDDCKQEA EVVIYETNCH 420
WADCTKEYDT QEQLVHHINN EHIHGEKKEF VCRWQACTRE QKPFKAQYML VVHMRRHTGE 480
KPHKCTFEGC SKAYSRLENL KTHLRSHTGE KPYVCEHEGC NKAFSNASDR AKHQNRTHSN 540
EKPYICKIPG CTKRYTDPSS LRKHVKTVHG PDAHVTKKQR NDVHVRAPLL KENGDNEASA 600
EPGGRGPEES VEASSTSHTV EDCLHIKAIK TESSGLCQSS PGAQSSCSSE PSPLGSAPNN 660
DSGMEMPGTG PGSLGDLTAL ADTCPGADTS ALAAPSTGGL QLRKHMSTVH RFEQLKREKL 720
KSLKDSCSWA GPAPHTRNTK LPPLPVNGSV LENFNNTGGG GPAGLLPSQR LPELTEVTML 780
SQLQERRDSS TSTMSSAYTV SRRSSGISPY FSSRRSSEAS PLGGLRPHNA SSADSYDPIS 840
TDASRRSSEA SQCSGGGPGL LNLTPAQQYN LRAKYAAATG GPPPTPLPGL DRVSLRTRLA 900
LLDAPERALP GACPHPLGPR RGSDGPTYSH GHGHGYAGAA PAFPHEGPNS STRRASDPVR 960
RPDPLILPRV QRFHSTHNMN PGSLPPCADR RGLHVQSHPS VDSNLTRNAY SPRPPSINEN 1020
VVMEAVAAGV DGPGLECDLG LVEDELVLPD DVVQYIKAHT GGTLDDGIRQ GYPTEGTGFP 1080
ENSKLPSPGL QGHRRLAAAD SNMGPSAPGL GGCQLSYSPS SNLNKSNMPV QWNEVSSGTV 1140
DALPTQVKPP PFPHSNLAVV QQKPAFGQYP GYNPQSVQSS SGGLDSTQPH LQLRGAPSAS 1200
RGSYTQQPRQ PAAGSQCLGM SAAMSPQASY SQAHPQLSPN IVSGSLNQFS PSCSNMAAKP 1260
SHLGLPQQME VVPNATIMNG HQREHGVPNS SLAAVSQPHP VLSYPQQDSY QQGSNLLSSH 1320
QPGFMESQQN AGFGLMQPRP PLEPNTASRH RGVRSGQQQL YARTTGQAMV TSANQETAEA 1380
MPKGPAGTMV SLAPQPSQDT GRAQDQNTLY YYGQIHMYEQ NGGCPAVQPQ PPQPQACSDS 1440
IQPEPLPSPG VNQVSSTVDS QLLEPPQIDF DAIMDDGDHS SLFSGALSPT LLHNLSQNSS 1500
RLTTPRNSLT LPSIPAGISN MAVGDMSSML TSLAEESKFL NMMT 1544 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0016020; C:membrane; IDA:MGI.
 GO:0031512; C:motile primary cilium; IDA:MGI.
 GO:0016607; C:nuclear speck; IDA:MGI.
 GO:0003682; F:chromatin binding; IDA:MGI.
 GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:MGI.
 GO:0044212; F:transcription regulatory region DNA binding; IDA:MGI.
 GO:0008270; F:zinc ion binding; IEA:Compara.
 GO:0006915; P:apoptotic process; IGI:MGI.
 GO:0007411; P:axon guidance; IMP:MGI.
 GO:0048754; P:branching morphogenesis of an epithelial tube; IMP:MGI.
 GO:0008283; P:cell proliferation; IGI:MGI.
 GO:0071407; P:cellular response to organic cyclic compound; IDA:MGI.
 GO:0021696; P:cerebellar cortex morphogenesis; IMP:MGI.
 GO:0090103; P:cochlea morphogenesis; IMP:MGI.
 GO:0048589; P:developmental growth; IMP:MGI.
 GO:0048566; P:embryonic digestive tract development; IMP:MGI.
 GO:0042733; P:embryonic digit morphogenesis; IMP:MGI.
 GO:0009913; P:epidermal cell differentiation; IEA:Compara.
 GO:0021508; P:floor plate formation; IMP:MGI.
 GO:0060322; P:head development; IMP:MGI.
 GO:0007507; P:heart development; IGI:MGI.
 GO:0007442; P:hindgut morphogenesis; IMP:MGI.
 GO:0001701; P:in utero embryonic development; IMP:MGI.
 GO:0001822; P:kidney development; IGI:MGI.
 GO:0030324; P:lung development; IMP:MGI.
 GO:0060603; P:mammary gland duct morphogenesis; IMP:MGI.
 GO:0032331; P:negative regulation of chondrocyte differentiation; IMP:MGI.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IGI:MGI.
 GO:0060032; P:notochord regression; IGI:MGI.
 GO:0042475; P:odontogenesis of dentin-containing tooth; IMP:MGI.
 GO:0002076; P:osteoblast development; IDA:MGI.
 GO:0021983; P:pituitary gland development; IGI:MGI.
 GO:0045740; P:positive regulation of DNA replication; IEA:Compara.
 GO:0045666; P:positive regulation of neuron differentiation; IGI:MGI.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0060513; P:prostatic bud formation; IMP:MGI.
 GO:0009954; P:proximal/distal pattern formation; IGI:MGI.
 GO:0008589; P:regulation of smoothened signaling pathway; IMP:MGI.
 GO:0009612; P:response to mechanical stimulus; IEA:Compara.
 GO:0001501; P:skeletal system development; IMP:MGI.
 GO:0060831; P:smoothened signaling pathway involved in dorsal/ventral neural tube patterning; IGI:MGI.
 GO:0021938; P:smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation; IMP:MGI.
 GO:0021776; P:smoothened signaling pathway involved in spinal cord motor neuron cell fate specification; IGI:MGI.
 GO:0021775; P:smoothened signaling pathway involved in ventral spinal cord interneuron specification; IGI:MGI.
 GO:0021965; P:spinal cord ventral commissure morphogenesis; IMP:MGI.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF00096; zf-C2H2 
SMART
 SM00355; ZnF_C2H2 
PROSITE
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS