CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032870
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Calcium channel voltage-dependent alpha1c subunit 
Protein Synonyms/Alias
  
Gene Name
 Cacna1c 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
63IDAARQAKLMGSAGNubiquitination[1]
1592AEYDPEAKGRIKHLDubiquitination[1]
1725KEQGLVGKPSQRNALubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Calcium; Calcium channel; Calcium transport; Ion channel; Ion transport; Membrane; Transmembrane; Transport; Voltage-gated channel. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2222 AA 
Protein Sequence
MVNENTRMYV PEENHQGSNY GSPRPAHANM NANAAAGLAP EHIPTPGAAL SWQAAIDAAR 60
QAKLMGSAGN ATISTVSSTQ RKRQQYGKPK KQGGTTATRP PRALLCLTLK NPIRRACISI 120
VEWKPFEIII LLTIFANCVA LAIYIPFPED DSNATNSNLE RVEYLFLIIF TVEAFLKVIA 180
YGLLFHPNAY LRNGWNLLDF IIVVVGLFSA ILEQATKADG ANALGGKGAG FDVKALRAFR 240
VLRPLRLVSG VPSLQVVLNS IIKAMVPLLH IALLVLFVII IYAIIGLELF MGKMHKTCYN 300
QEGIIDVPAE EDPSPCALET GHGRQCQNGT VCKPGWDGPK HGITNFDNFA FAMLTVFQCI 360
TMEGWTDVLY WVNDAVGRDW PWIYFVTLII IGSFFVLNLV LGVLSGEFSK EREKAKARGD 420
FQKLREKQQL EEDLKGYLDW ITQAEDIDPE NEDEGMDEDK PRNRGAPAGL HDQKKGKFAW 480
FSHSTETHMS MPTSETESVN TENVAGGDIE GENCGARLAH RISKSKFSRY WRRWNRFCRR 540
KCRAAVKSNV FYWLVIFLVF LNTLTIASEH YNQPHWLTEV QDTANKALLA LFTAEMLLKM 600
YSLGLQAYFV SLFNRFDCFI VCGGILETIL VETKIMSPLG ISVLRCVRLL RIFKITRYWN 660
SLSNLVASLL NSVRSIASLL LLLFLFIIIF SLLGMQLFGG KFNFDEMQTR RSTFDNFPQS 720
LLTVFQILTG EDWNSVMYDG IMAYGGPSFP GMLVCIYFII LFICGNYILL NVFLAIAVDN 780
LADAESLTSA QKEEEEEKER KKLARTASPE KKQEVMEKPA VEESKEEKIE LKSITADGES 840
PPTTKINMDD LQPSENEDKS PHSNPDTAGE EDEEEPEMPV GPRPRPLSEL HLKEKAVPMP 900
EASAFFIFSP NNRFRLQCHR IVNDTIFTNL ILFFILLSSI SLAAEDPVQH TSFRNHILGN 960
ADYVFTSIFT LEIILKMTAY GAFLHKGSFC RNYFNILDLL VVSVSLISFG IQSSAINVVK 1020
ILRVLRVLRP LRAINRAKGL KHVVQCVFVA IRTIGNIVIV TTLLQFMFAC IGVQLFKGKL 1080
YTCSDSSKQT EAECKGNYIT YKDGEVDHPI IQPRSWENSK FDFDNVLAAM MALFTVSTFE 1140
GWPELLYRSI DSHTEDKGPI YNYRVEISIF FIIYIIIIAF FMMNIFVGFV IVTFQEQGEQ 1200
EYKNCELDKN QRQCVEYALK ARPLRRYIPK NQHQYKVWYV VNSTYFEYLM FVLILLNTIC 1260
LAMQHYGQSC LFKIAMNILN MLFTGLFTVE MILKLIAFKP KHYFCDAWNT FDALIVVGSI 1320
VDIAITEVHP AEHTQCSPSM VRTTLQTTFP ASVAPPLATH VLSTLISRAL GTQPSSHCMW 1380
PPCPLCALTA CAHVSCARSA EENSRISITF FRLFRVMRLV KLLSRGEGIR TLLWTFIKSF 1440
QALPYVALLI VMLFFIYAVI GMQVFGKIAL NDTTEINRNN NFQTFPQAVL LLFRCATGEA 1500
WQDIMLACMP GKKCAPESEP SNSTEGETPC GSSFAVFYFI SFYMLCAFLI INLFVAVIMD 1560
NFDYLTRDWS ILGPHHLDEF KRIWAEYDPE AKGRIKHLDV VTLLRRIQPP LGFGKLCPHR 1620
VACKRLVSMN MPLNSDGTVM FNATLFALVR TALRIKTEGN LEQANEELRA IIKKIWKRTS 1680
MKLLDQVVPP AGDDEVTVGK FYATFLIQEY FRKFKKRKEQ GLVGKPSQRN ALSLQAGLRT 1740
LHDIGPEIRR AISGDLTAEE ELDKAMKEAV SAASEDDIFR RAGGLFGNHV TYYQSDSRGN 1800
FPQTFATQRP LHINKTGNNQ ADTESPSHEK LVDSTFTPSS YSSTGSNANI NNANNTALGR 1860
FPHPAGYSST VSTVEGHGPP LSPAVRVQEA AWKLSSKRCH SRESQGATVN QEIFPDETRS 1920
VRMSEEAEYC SEPSLLSTDM FSYQEDEHRQ LTCPEEDKRE IQPSPKRSFL RSASLGRRAS 1980
FHLECLKRQK DQGGDISQKT ALPLHLVHHQ ALAVAGLSPL LQRSHSPTTF PRPCPTPPVT 2040
PGSRGRPLRP IPTLRLEGAE SSEKLNSSFP SIHCSSWSEE TTACSGSSSM ARRARPVSLT 2100
VPSQAGAPGR QFHGSASSLV EAVLISEGLG QFAQDPKFIE VTTQELADAC DMTIEEMENA 2160
ADNILSGGAQ QSPNGTLLPF VNCRDPGQDR AVAPEDESCA YALGRGRSEE ALADSRSYVS 2220
NL 2222 
Gene Ontology
 GO:0002095; C:caveolar macromolecular signaling complex; IDA:MGI.
 GO:0043198; C:dendritic shaft; IDA:MGI.
 GO:0043025; C:neuronal cell body; IDA:MGI.
 GO:0030315; C:T-tubule; TAS:MGI.
 GO:0005891; C:voltage-gated calcium channel complex; TAS:MGI.
 GO:0030018; C:Z disc; IDA:MGI.
 GO:0005245; F:voltage-gated calcium channel activity; IDA:MGI.
 GO:0007628; P:adult walking behavior; IGI:MGI.
 GO:0017156; P:calcium ion-dependent exocytosis; IMP:MGI.
 GO:0006874; P:cellular calcium ion homeostasis; IMP:MGI.
 GO:0042593; P:glucose homeostasis; IMP:MGI.
 GO:0030252; P:growth hormone secretion; IDA:MGI.
 GO:0030073; P:insulin secretion; IMP:MGI.
 GO:0008217; P:regulation of blood pressure; IMP:MGI.
 GO:0046620; P:regulation of organ growth; IMP:MGI.
 GO:0019229; P:regulation of vasoconstriction; IMP:MGI.
 GO:0060083; P:smooth muscle contraction involved in micturition; IMP:MGI.
 GO:0007268; P:synaptic transmission; IMP:MGI.
 GO:0008542; P:visual learning; IMP:MGI. 
Interpro
 IPR005821; Ion_trans_dom.
 IPR027359; K_channel_four-helix_dom.
 IPR014873; VDCC_a1su_IQ.
 IPR005451; VDCC_L_a1csu.
 IPR005446; VDCC_L_a1su.
 IPR002077; VDCCAlpha1. 
Pfam
 PF08763; Ca_chan_IQ
 PF00520; Ion_trans 
SMART
 SM01062; Ca_chan_IQ 
PROSITE
  
PRINTS
 PR00167; CACHANNEL.
 PR01630; LVDCCALPHA1.
 PR01635; LVDCCALPHA1C.