UniProt Accession

 E9PGE5_HUMAN; E9PGE5 

Genbank Protein ID

 AC078783; AC093003 

Genbank Nucleotide ID

  

Protein Name

 TBC1 domain family member 23 

Protein Synonyms/Alias

  

Gene Name

 TBC1D23 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
358	NKMTVALKTKSVNVR	ubiquitination	[1, 2]
367	KSVNVREKVISFIEN	ubiquitination	[2]
511	VVKITSKKKHPELIT	ubiquitination	[3]

Reference

 [1] A data set of human endogenous protein ubiquitination sites.
 Shi Y, Chan DW, Jung SY, Malovannaya A, Wang Y, Qin J.
 Mol Cell Proteomics. 2011 May;10(5):M110.002089. [PMID: 20972266]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.
 Danielsen JM, Sylvestersen KB, Bekker-Jensen S, Szklarczyk D, Poulsen JW, Horn H, Jensen LJ, Mailand N, Nielsen ML.
 Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. [PMID: 21139048] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 562 AA 

Protein Sequence

Gene Ontology

 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0005097; F:Rab GTPase activator activity; IEA:InterPro.
 GO:0032851; P:positive regulation of Rab GTPase activity; IEA:GOC. 

Interpro

 IPR000195; Rab-GTPase-TBC_dom.
 IPR001763; Rhodanese-like_dom. 

Pfam

 PF00566; RabGAP-TBC
 PF00581; Rhodanese 

SMART

  

PROSITE

 PS50206; RHODANESE_3
 PS50086; TBC_RABGAP 

PRINTS