UniProt Accession

 G3V5T9_HUMAN; G3V5T9 

Genbank Protein ID

 AC025162; AC034102; CH471054 

Genbank Nucleotide ID

 EAW96859.1 

Protein Name

 Cyclin-dependent kinase 2 

Protein Synonyms/Alias

 Cyclin-dependent kinase 2, isoform CRA_c 

Gene Name

 CDK2 

Gene Synonyms/Alias

 hCG_24992 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
6	**MENFQKVEKIGEG	ubiquitination	[1]
9	ENFQKVEKIGEGTYG	ubiquitination	[1]
20	GTYGVVYKARNKLTG	ubiquitination	[1]
24	VVYKARNKLTGEVVA	ubiquitination	[1]
33	TGEVVALKKIRLDTE	ubiquitination	[1]
56	IREISLLKELNHPNI	ubiquitination	[1, 2]
129	RVLHRDLKPQNLLIN	ubiquitination	[1]
285	VTSMPDYKPSFPKWA	ubiquitination	[1]
290	DYKPSFPKWARQDFS	ubiquitination	[1]
298	WARQDFSKVVPPLDE	ubiquitination	[1, 3]
321	MLHYDPNKRISAKAA	ubiquitination	[1]
326	PNKRISAKAALAHPF	ubiquitination	[1]
339	PFFQDVTKPVPHLRL	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

  

Sequence Annotation

  

Keyword

 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 346 AA 

Protein Sequence

Gene Ontology

 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro. 

Interpro

 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 

Pfam

 PF00069; Pkinase 

SMART

 SM00220; S_TKc 

PROSITE

 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 

PRINTS