CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036864
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Filamin-B 
Protein Synonyms/Alias
  
Gene Name
 FLNB 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
326GVTMKGPKGLEELVKubiquitination[1, 2, 3]
333KGLEELVKQKDFLDGacetylation[4]
382GPEAGMQKVRAWGPGubiquitination[2]
512DAGKAPLKIFAQDGEacetylation[4, 5]
512DAGKAPLKIFAQDGEubiquitination[1]
528QRIDIQMKNRMDGTYubiquitination[2]
1280SFTVDSSKAGLAPLEacetylation[4]
1564VIPFAVRKGEITGEVubiquitination[6]
1704ILVKYNDKHIPGSPFacetylation[4]
1704ILVKYNDKHIPGSPFubiquitination[1]
1762RDEPCLLKRLPNNHIubiquitination[1, 3]
1977GVHTVSVKYRGQHVTacetylation[4]
2123AIRLNGAKGKIDAKVubiquitination[7]
2149VSELEPDKYAVRFIPacetylation[4]
2383YNVTYVVKERGDYVLacetylation[4]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [5] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [6] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [7] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2409 AA 
Protein Sequence
MQEHSTRRRS LSLCPDWESW DPQKPVDNAR EAMQQADDWL GVPQVITPEE IIHPDVDEHS 60
VMTYLSQFPK AKLKPGAPLK PKLNPKKARA YGRGIEPTGN MVKQPAKFTV DTISAGQGDV 120
MVFVEDPEGN KEEAQVTPDS DKNKTYSVEY LPKVTGLHKV TVLFAGQHIS KSPFEVSVDK 180
AQGDASKVTA KGPGLEAVGN IANKPTYFDI YTAGAGVGDI GVEVEDPQGK NTVELLVEDK 240
GNQVYRCVYK PMQPGPHVVK IFFAGDTIPK SPFVVQVGEA CNPNACRASG RGLQPKGVRI 300
RETTDFKVDT KAAGSGELGV TMKGPKGLEE LVKQKDFLDG VYAFEYYPST PGRYSIAITW 360
GGHHIPKSPF EVQVGPEAGM QKVRAWGPGL HGGIVGRSAD FVVESIGSEV GSLGFAIEGP 420
SQAKIEYNDQ NDGSCDVKYW PKEPGEYAVH IMCDDEDIKD SPYMAFIHPA TGGYNPDLVR 480
AYGPGLEKSG CIVNNLAEFT VDPKDAGKAP LKIFAQDGEG QRIDIQMKNR MDGTYACSYT 540
PVKAIKHTIA VVWGGVNIPH SPYRVNIGQG SHPQKVKVFG PGVERSGLKA NEPTHFTVDC 600
TEAGEGDVSV GIKCDARVLS EDEEDVDFDI IHNANDTFTV KYVPPAAGRY TIKVLFASQE 660
IPASPFRVKV DPSHDASKVK AEGPGLSKAG VENGKPTHFT VYTKGAGKAP LNVQFNSPLP 720
GDAVKDLDII DNYDYSHTVK YTPTQQGNMQ VLVTYGGDPI PKSPFTVGVA APLDLSKIKL 780
NGLENRVEVG KDQEFTVDTR GAGGQGKLDV TILSPSRKVV PCLVTPVTGR ENSTAKFIPR 840
EEGLYAVDVT YDGHPVPGSP YTVEASLPPD PSKVKAHGPG LEGGLVGKPA EFTIDTKGAG 900
TGGLGLTVEG PCEAKIECSD NGDGTCSVSY LPTKPGEYFV NILFEEVHIP GSPFKADIEM 960
PFDPSKVVAS GPGLEHGKVG EAGLLSVDCS EAGPGALGLE AVSDSGTKAE VSIQNNKDGT 1020
YAVTYVPLTA GMYTLTMKYG GELVPHFPAR VKVEPAVDTS RIKVFGPGIE GKDVFREATT 1080
DFTVDSRPLT QVGGDHIKAH IANPSGASTE CFVTDNADGT YQVEYTPFEK GLHVVEVTYD 1140
DVPIPNSPFK VAVTEGCQPS RVQAQGPGLK EAFTNKPNVF TVVTRGAGIG GLGITVEGPS 1200
ESKINCRDNK DGSCSAEYIP FAPGDYDVNI TYGGAHIPGS PFRVPVKDVV DPSKVKIAGP 1260
GLGSGVRARV LQSFTVDSSK AGLAPLEVRV LGPRGLVEPV NVVDNGDGTH TVTYTPSQEG 1320
PYMVSVKYAD EEIPRSPFKV KVLPTYDASK VTASGPGLSS YGVPASLPVD FAIDARDAGE 1380
GLLAVQITDQ EGKPKRAIVH DNKDGTYAVT YIPDKTGRYM IGVTYGGDDI PLSPYRIRAT 1440
QTGDASKCLA TGPGIASTVK TGEEVGFVVD AKTAGKGKVT CTVLTPDGTE AEADVIENED 1500
GTYDIFYTAA KPGTYVIYVR FGGVDIPNSP FTVMVTEEAY VPVSDMNGLG FKPFDLVIPF 1560
AVRKGEITGE VHMPSGKTAT PEIVDNKDGT VTVRYAPTEV GLHEMHIKYM GSHIPESPLQ 1620
FYVNYPNSGS VSAYGPGLVY GVANKTATFT IVTEDAGEGG LDLAIEGPSK AEISCIDNKD 1680
GTCTVTYLPT LPGDYSILVK YNDKHIPGSP FTAKITDDSR RCSQVKLGSA ADFLLDISET 1740
DLSSLTASIK APSGRDEPCL LKRLPNNHIG ISFIPREVGE HLVSIKKNGN HVANSPVSIM 1800
VVQSEIGDAR RAKVYGRGLS EGRTFEMSDF IVDTRDAGYG GISLAVEGPS KVDIQTEDLE 1860
DGTCKVSYFP TVPGVYIVST KFADEHVPGS PFTVKISGEG RVKESITRTS RAPSVATVGS 1920
ICDLNLKIPE INSSDMSAHV TSPSGRVTEA EIVPMGKNSH CVRFVPQEMG VHTVSVKYRG 1980
QHVTGSPFQF TVGPLGEGGA HKVRAGGPGL ERGEAGVPAE FSIWTREAGA GGLSIAVEGP 2040
SKAEITFDDH KNGSCGVSYI AQEPGNYEVS IKFNDEHIPE SPYLVPVIAP SDDARRLTVM 2100
SLQESGLKVN QPASFAIRLN GAKGKIDAKV HSPSGAVEEC HVSELEPDKY AVRFIPHENG 2160
VHTIDVKFNG SHVVGSPFKV RVGEPGQAGN PALVSAYGTG LEGGTTGIQS EFFINTTRAG 2220
PGTLSVTIEG PSKVKMDCQE TPEGYKVMYT PMAPGNYLIS VKYGGPNHIV GSPFKAKVTG 2280
QRLVSPGSAN ETSSILVESV TRSSTETCYS AIPKASSDAS KVTSKGAGLS KAFVGQKSSF 2340
LVDCSKAGSN MLLIGVHGPT TPCEEVSMKH VGNQQYNVTY VVKERGDYVL AVKWGEEHIP 2400
GSPFHVTVP 2409 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005886; C:plasma membrane; IDA:HPA. 
Interpro
 IPR001715; CH-domain.
 IPR001298; Filamin.
 IPR017868; Filamin/ABP280_repeat-like.
 IPR013783; Ig-like_fold.
 IPR014756; Ig_E-set. 
Pfam
 PF00630; Filamin 
SMART
 SM00557; IG_FLMN 
PROSITE
 PS50194; FILAMIN_REPEAT 
PRINTS