CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028362
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Fas 
Protein Synonyms/Alias
  
Gene Name
 Fas 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
238DMTIQEAKKFARENNubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
  
Keyword
  
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 327 AA 
Protein Sequence
MLWIWAVLPL VLAGSQLRVH TQGTNSISES LKLRRRVRET DKNCSEGLYQ GGPFCCQLCS 60
PGEKKVEDCK TNGGKPICTS CTEGKEYMDK KHYADKCRRC TLCDEEHGLE VETNCTPTQN 120
TKCKCKPDFY CDSSGCEHCV RCTSCEHGTL EPCTATSNTN CRKQSPRNRL WLLTILVLLI 180
PLVFIYRKYR KRKCWKRRQD DPESRTSSHE TIPMNASNLS LSKYIPRIAE DMTIQEAKKF 240
ARENNIKEGK IDEIIHDNIQ DTAEQKVQLL LCWYQSHGKS DAYQDLIKGL KKAECRRTLD 300
KFQDMVQKDL GNSTPDIGNE NEGQCLE 327 
Gene Ontology
 GO:0009897; C:external side of plasma membrane; IDA:MGI.
 GO:0005576; C:extracellular region; IDA:MGI.
 GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
 GO:0006924; P:activation-induced cell death of T cells; IDA:MGI.
 GO:0019724; P:B cell mediated immunity; IMP:MGI.
 GO:0071285; P:cellular response to lithium ion; IMP:MGI.
 GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IMP:MGI.
 GO:0008625; P:extrinsic apoptotic signaling pathway via death domain receptors; IDA:MGI.
 GO:0010467; P:gene expression; IMP:MGI.
 GO:0002377; P:immunoglobulin production; IMP:MGI.
 GO:0006925; P:inflammatory cell apoptotic process; IDA:MGI.
 GO:0097049; P:motor neuron apoptotic process; IMP:MGI.
 GO:0043066; P:negative regulation of apoptotic process; IDA:MGI.
 GO:0050869; P:negative regulation of B cell activation; IMP:MGI.
 GO:0045060; P:negative thymic T cell selection; IMP:MGI.
 GO:0043065; P:positive regulation of apoptotic process; IGI:MGI.
 GO:0051260; P:protein homooligomerization; IDA:MGI.
 GO:0045619; P:regulation of lymphocyte differentiation; IMP:MGI.
 GO:0045637; P:regulation of myeloid cell differentiation; IMP:MGI.
 GO:0003014; P:renal system process; IMP:MGI.
 GO:0051384; P:response to glucocorticoid stimulus; IMP:MGI.
 GO:0009636; P:response to toxic substance; IMP:MGI.
 GO:0048536; P:spleen development; IMP:MGI.
 GO:0006927; P:transformed cell apoptotic process; IDA:MGI. 
Interpro
 IPR011029; DEATH-like_dom.
 IPR000488; Death_domain.
 IPR008063; Fas_rcpt.
 IPR001368; TNFR/NGFR_Cys_rich_reg. 
Pfam
 PF00531; Death
 PF00020; TNFR_c6 
SMART
 SM00005; DEATH
 SM00208; TNFR 
PROSITE
 PS50017; DEATH_DOMAIN
 PS50050; TNFR_NGFR_2 
PRINTS
 PR01680; TNFACTORR6.