UniProt Accession

 NDK_GEOKA; Q5KXU2 

Genbank Protein ID

 BA000043 

Genbank Nucleotide ID

 BAD76494.1 

Protein Name

 Nucleoside diphosphate kinase 

Protein Synonyms/Alias

 NDK; NDP kinase; Nucleoside-2-P kinase 

Gene Name

 ndk 

Gene Synonyms/Alias

 GK2209 

Created Date

 July 27, 2013 

Organism

 Geobacillus kaustophilus (strain HTA426) 

NCBI Taxa ID

 235909 

Lysine Modification

Position	Peptide	Type	References
10	ERTFIMVKPDGVQRN	acetylation	[1]
125	SDSPQSAKREISLFF	acetylation	[1]

Reference

 [1] Proteomic analysis of acetylation in thermophilic Geobacillus kaustophilus.
 Lee DW, Kim D, Lee YJ, Kim JA, Choi JY, Kang S, Pan JG.
 Proteomics. 2013 Aug;13(15):2278-82. [PMID: 23696451] 

Functional Description

 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). 

Sequence Annotation

 ACT_SITE 116 116 Pros-phosphohistidine intermediate (By
 BINDING 10 10 ATP (By similarity).
 BINDING 58 58 ATP (By similarity).
 BINDING 86 86 ATP (By similarity).
 BINDING 92 92 ATP (By similarity).
 BINDING 103 103 ATP (By similarity).
 BINDING 113 113 ATP (By similarity).
 MOD_RES 92 92 Phosphothreonine (By similarity).
 MOD_RES 123 123 Phosphoserine (By similarity).  

Keyword

 ATP-binding; Complete proteome; Cytoplasm; Kinase; Magnesium; Metal-binding; Nucleotide metabolism; Nucleotide-binding; Phosphoprotein; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 149 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:HAMAP.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004550; F:nucleoside diphosphate kinase activity; IEA:HAMAP.
 GO:0006241; P:CTP biosynthetic process; IEA:HAMAP.
 GO:0006183; P:GTP biosynthetic process; IEA:HAMAP.
 GO:0006228; P:UTP biosynthetic process; IEA:HAMAP. 

Interpro

 IPR001564; Nucleoside_diP_kinase.
 IPR023005; Nucleoside_diP_kinase_AS. 

Pfam

 PF00334; NDK 

SMART

 SM00562; NDK 

PROSITE

 PS00469; NDP_KINASES 

PRINTS

 PR01243; NUCDPKINASE.