CPLM-021969

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-021969

UniProt Accession

INO1_HUMAN; Q9NPH2; B3KRT1; G5E9U0; Q6NXT5; Q7Z525; Q9BT65; Q9H2Y2; Q9NSU0; Q9NVW7

Genbank Protein ID

AF207640; AF220530; AF220259; AF220250; AF220251; AF220252; AF220253; AF220254; AF220255; AF220256; AF220257; AF220258; AF086921; AK001325; AK021526; AK092179; AL137749; AC008397; CH471106; CH471106; BC004320; BC018952; BC066902

Genbank Nucleotide ID

AAG35698.1; AAF26444.1; AAF26739.1; AAF26739.1; AAF26739.1; AAF26739.1; AAF26739.1; AAF26739.1; AAF26739.1; AAF26739.1; AAF26739.1; AAF26739.1; AAP97151.1; BAA91626.1; BAB13837.1; BAG52493.1; CAB70904.1; EAW84703.1; EAW84705.1; AAH04320.1; AAH18952.1; AAH66902.1

Protein Name

Inositol-3-phosphate synthase 1

Protein Synonyms/Alias

IPS 1; Myo-inositol 1-phosphate synthase; MI-1-P synthase; MIP synthase; hIPS; Myo-inositol 1-phosphate synthase A1; hINO1

Gene Name

ISYNA1

Gene Synonyms/Alias

INO1

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
94	RSSAGLDKVIVLWTA	ubiquitination	[1]
177	FVGGDDFKSGQTKVK	ubiquitination	[1]
184	KSGQTKVKSVLVDFL	ubiquitination	[1]
265	VPYVGDSKRALDEYT	ubiquitination	[1]
402	ATYPMLNKKGPVPAA	ubiquitination	[1]

Reference

[1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]

Functional Description

Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds.

Sequence Annotation

Keyword

Alternative splicing; Complete proteome; Cytoplasm; Inositol biosynthesis; Isomerase; Lipid biosynthesis; Lipid metabolism; NAD; Phospholipid biosynthesis; Phospholipid metabolism; Reference proteome.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

558 AA

Protein Sequence

MVAPNDLVFD GWDISSLNLA EAMRRAKVLD WGLQEQLWPH MEALRPRPSV YIPEFIAANQ 60
SARADNLIPG SRAQQLEQIR RDIRDFRSSA GLDKVIVLWT ANTERFCEVI PGLNDTAENL 120
LRTIELGLEV SPSTLFAVAS ILEGCAFLNG SPQNTLVPGA LELAWQHRVF VGGDDFKSGQ 180
TKVKSVLVDF LIGSGLKTMS IVSYNHLGNN DGENLSAPLQ FRSKEVSKSN VVDDMVQSNP 240
VLYTPGEEPD HCVVIKYVPY VGDSKRALDE YTSELMLGGT NTLVLHNTCE DSLLAAPIML 300
DLALLTELCQ RVSFCTDMDP EPQTFHPVLS LLSFLFKAPL VPPGSPVVNA LFRQRSCIEN 360
ILRACVGLPP QNHMLLEHKM ERPGPSLKRV GPVAATYPML NKKGPVPAAT NGCTGDANGH 420
LQEEPPMPTT 430

Gene Ontology

GO:0005829; C:cytosol; TAS:Reactome.
GO:0004512; F:inositol-3-phosphate synthase activity; TAS:Reactome.
GO:0006021; P:inositol biosynthetic process; IEA:UniProtKB-UniPathway.
GO:0043647; P:inositol phosphate metabolic process; TAS:Reactome.
GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-KW.

Interpro

IPR002587; Myo-inos-1-P_Synthase.
IPR013021; Myo-inos-1-P_Synthase_GAPDH.
IPR016040; NAD(P)-bd_dom.

Pfam

PF01658; Inos-1-P_synth
PF07994; NAD_binding_5

SMART

PROSITE

PRINTS