UniProt Accession

 PGDH_MOUSE; Q8VCC1; Q61106 

Genbank Protein ID

 U44389; AK146038; BC021157 

Genbank Nucleotide ID

 AAB41825.1; BAE26850.1; AAH21157.1 

Protein Name

 15-hydroxyprostaglandin dehydrogenase [NAD(+)] 

Protein Synonyms/Alias

 15-PGDH; Prostaglandin dehydrogenase 1 

Gene Name

 Hpgd 

Gene Synonyms/Alias

 Pgdh1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
69	QCDVADQKQLRDTFR	ubiquitination	[1]
173	AMAANLMKSGVRLNV	ubiquitination	[1]
207	MGQYIEYKDQIKAMM	ubiquitination	[1]
211	IEYKDQIKAMMKFYG	ubiquitination	[1]
249	IMKITASKGIHFQDY	ubiquitination	[1]
264	DISPLLVKAPLTS**	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4 (By similarity). 

Sequence Annotation

 NP_BIND 12 20 NAD (By similarity).
 NP_BIND 36 37 NAD (By similarity).
 NP_BIND 63 65 NAD (By similarity).
 NP_BIND 151 155 NAD (By similarity).
 NP_BIND 186 188 NAD (By similarity).
 ACT_SITE 151 151 Proton acceptor (By similarity).
 BINDING 91 91 NAD; via carbonyl oxygen (By similarity).
 BINDING 138 138 Substrate (By similarity).
 BINDING 148 148 Substrate (By similarity).  

Keyword

 Complete proteome; Cytoplasm; Fatty acid metabolism; Lipid metabolism; NAD; Oxidoreductase; Prostaglandin metabolism; Reference proteome; Tumor suppressor. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 269 AA 

Protein Sequence

Gene Ontology

 GO:0016323; C:basolateral plasma membrane; IDA:MGI.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0016404; F:15-hydroxyprostaglandin dehydrogenase (NAD+) activity; ISS:UniProtKB.
 GO:0070403; F:NAD+ binding; ISS:UniProtKB.
 GO:0004957; F:prostaglandin E receptor activity; ISS:UniProtKB.
 GO:0097070; P:ductus arteriosus closure; IMP:UniProtKB.
 GO:0007565; P:female pregnancy; ISS:UniProtKB.
 GO:0045786; P:negative regulation of cell cycle; ISS:UniProtKB.
 GO:0030728; P:ovulation; ISS:UniProtKB.
 GO:0007567; P:parturition; ISS:UniProtKB.
 GO:0006693; P:prostaglandin metabolic process; ISS:UniProtKB.
 GO:0070493; P:thrombin receptor signaling pathway; ISS:UniProtKB.
 GO:0007179; P:transforming growth factor beta receptor signaling pathway; ISS:UniProtKB. 

Interpro

 IPR002198; DH_sc/Rdtase_SDR.
 IPR002347; Glc/ribitol_DH.
 IPR016040; NAD(P)-bd_dom.
 IPR020904; Sc_DH/Rdtase_CS. 

Pfam

 PF00106; adh_short 

SMART

  

PROSITE

 PS00061; ADH_SHORT 

PRINTS

 PR00081; GDHRDH.
 PR00080; SDRFAMILY.