| Tag | Content |
|---|
| CPLM ID | CPLM-004088 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Uracil-DNA glycosylase |
Protein Synonyms/Alias | UDG |
Gene Name | UNG |
Gene Synonyms/Alias | DGU; UNG1; UNG15 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 69 | LDRIQRNKAAALLRL | ubiquitination | [1] |
|
Reference | [1] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI. J Proteome Res. 2012 Feb 3;11(2):796-807. [ PMID: 22053931] |
Functional Description | Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. |
Sequence Annotation | REGION 1 25 FAM72A-binding.
ACT_SITE 154 154 Proton acceptor (By similarity).
MOD_RES 12 12 Phosphoserine.
MOD_RES 14 14 Phosphoserine.
MOD_RES 23 23 Phosphoserine.
MOD_RES 60 60 Phosphothreonine.
MOD_RES 64 64 Phosphoserine.
MOD_RES 295 295 N6-acetyllysine. |
Keyword | 3D-structure; Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Disease mutation; DNA damage; DNA repair; Glycosidase; Host-virus interaction; Hydrolase; Mitochondrion; Nucleus; Phosphoprotein; Polymorphism; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 313 AA |
Protein Sequence | MGVFCLGPWG LGRKLRTPGK GPLQLLSRLC GDHLQAIPAK KAPAGQEEPG TPPSSPLSAE 60
QLDRIQRNKA AALLRLAARN VPVGFGESWK KHLSGEFGKP YFIKLMGFVA EERKHYTVYP 120
PPHQVFTWTQ MCDIKDVKVV ILGQDPYHGP NQAHGLCFSV QRPVPPPPSL ENIYKELSTD 180
IEDFVHPGHG DLSGWAKQGV LLLNAVLTVR AHQANSHKER GWEQFTDAVV SWLNQNSNGL 240
VFLLWGSYAQ KKGSAIDRKR HHVLQTAHPS PLSVYRGFFG CRHFSKTNEL LQKSGKKPID 300
WKEL 304 |
Gene Ontology | GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; NAS:UniProtKB. GO:0004844; F:uracil DNA N-glycosylase activity; NAS:UniProtKB. GO:0006284; P:base-excision repair; TAS:ProtInc. GO:0016446; P:somatic hypermutation of immunoglobulin genes; IEA:Compara. GO:0016447; P:somatic recombination of immunoglobulin gene segments; IEA:Compara. GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |