CPLM-017069

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-017069

UniProt Accession

KLHL7_HUMAN; Q8IXQ5; A4D144; B7Z5I9; G5E9G3; Q7Z765; Q96MV2; Q9BQF8; Q9UDQ9

Genbank Protein ID

AF111113; AL136597; AK056390; AK299006; EF560731; AC005082; AC006039; AC073992; CH236948; CH471073; CH471073; CH471073; BC009555; BC039585

Genbank Nucleotide ID

AAF27196.1; CAB66532.1; BAB71175.1; BAH12925.1; ABQ59041.1; AAO21916.1; EAL24261.1; EAW93770.1; EAW93773.1; EAW93774.1; AAH09555.1; AAH39585.1

Protein Name

Kelch-like protein 7

Protein Synonyms/Alias

Gene Name

KLHL7

Gene Synonyms/Alias

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
166	EFLQLDVKRVTHLLN	ubiquitination	[1]
482	NVEYYDIKLNEWKMV	ubiquitination	[1]
538	DKWVANSKVRAFPVT	ubiquitination	[1]

Reference

[1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]

Functional Description

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL7) complex acts by mediating ubiquitination and subsequent degradation of substrate proteins. Probably mediates 'Lys-48'-linked ubiquitination.

Sequence Annotation

DOMAIN 44 111 BTB.
DOMAIN 146 248 BACK.
REPEAT 294 336 Kelch 1.
REPEAT 337 382 Kelch 2.
REPEAT 383 430 Kelch 3.
REPEAT 431 481 Kelch 4.
REPEAT 483 528 Kelch 5.
REPEAT 530 575 Kelch 6.

Keyword

3D-structure; Alternative splicing; Complete proteome; Disease mutation; Kelch repeat; Nucleus; Polymorphism; Reference proteome; Repeat; Retinitis pigmentosa; Ubl conjugation pathway.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

586 AA

Protein Sequence

MLGGTDCRTF LTSHINLKKT LCDVILMVQE RKIPAHRVVL AAASHFFNLM FTTNMLESKS 60
FEVELKDAEP DIIEQLVEFA YTARISVNSN NVQSLLDAAN QYQIEPVKKM CVDFLKEQVD 120
ASNCLGISVL AECLDCPELK ATADDFIHQH FTEVYKTDEF LQLDVKRVTH LLNQDTLTVR 180
AEDQVYDAAV RWLKYDEPNR QPFMVDILAK VRFPLISKNF LSKTVQAEPL IQDNPECLKM 240
VISGMRYHLL SPEDREELVD GTRPRRKKHD YRIALFGGSQ PQSCRYFNPK DYSWTDIRCP 300
FEKRRDAACV FWDNVVYILG GSQLFPIKRM DCYNVVKDSW YSKLGPPTPR DSLAACAAEG 360
KIYTSGGSEV GNSALYLFEC YDTRTESWHT KPSMLTQRCS HGMVEANGLI YVCGGSLGNN 420
VSGRVLNSCE VYDPATETWT ELCPMIEARK NHGLVFVKDK IFAVGGQNGL GGLDNVEYYD 480
IKLNEWKMVS PMPWKGVTVK CAAVGSIVYV LAGFQGVGRL GHILEYNTET DKWVANSKVR 540
AFPVTSCLIC VVDTCGANEE TLET 564

Gene Ontology

GO:0031463; C:Cul3-RING ubiquitin ligase complex; IDA:UniProtKB.
GO:0005737; C:cytoplasm; IDA:HPA.
GO:0005730; C:nucleolus; IDA:LIFEdb.
GO:0005886; C:plasma membrane; IDA:HPA.
GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
GO:0016567; P:protein ubiquitination; IDA:UniProtKB.

Interpro

IPR011705; BACK.
IPR000210; BTB/POZ-like.
IPR011333; BTB/POZ_fold.
IPR013069; BTB_POZ.
IPR017096; Kelch-like_gigaxonin.
IPR015915; Kelch-typ_b-propeller.
IPR006652; Kelch_1.

Pfam

PF07707; BACK
PF00651; BTB
PF01344; Kelch_1

SMART

SM00875; BACK
SM00225; BTB
SM00612; Kelch

PROSITE

PS50097; BTB

PRINTS