Tag | Content |
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CPLM ID | CPLM-018138 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Nicalin |
Protein Synonyms/Alias | Nicastrin-like protein |
Gene Name | Ncln |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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99 | FSYEHYQKALRQSAG | ubiquitination | [1] |
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Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning (By similarity). |
Sequence Annotation | CARBOHYD 241 241 N-linked (GlcNAc...) (Potential). CARBOHYD 428 428 N-linked (GlcNAc...) (Potential). |
Keyword | Complete proteome; Endoplasmic reticulum; Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 563 AA |
Protein Sequence | MLEEAGEVLE NVLKASCLPL GFIVFLPAVL LLVAPPLPAA DAAHEFTVYR MQQYDLQGQP 60 YGTRNAVLNT EARTVDADVL SRRCVLMRLL DFSYEHYQKA LRQSAGAVVI ILPRAMAAVP 120 QDVVRQFMEI EPEMLAMETV VPVYFAVEDE ALLSIYEQTQ AASASQGSAS AAEVLLHTAT 180 ANGFQMVTSG AQSQAVSDWL ITSVEGRLTG LGGEDLPTIV IVAHYDAFGV APWLSLGADS 240 NGSGISVLLE LARLFSRLYT YKRTHAAYNL LFFASGGGKF NYQGTKRWLE DSLDHTDSSL 300 LQDNVAFVLC LDTVGRGSHL RLHVSKPPRE GTLQHAFLRE LETVAAHQFP DVSFSMVHKK 360 INLADDVLAW EHERFAIRRL PAFTLSHLES HRAGPRSSIM DVRSRVDSKT LTRNTRIIAE 420 ALTRVIYNLT EKGTPPDMPV FTEQMQVQEE QIDSVMDWLT NQPRAAQLLD KDGTFLSTLE 480 HFLSRYLKDV RQHHVKADKR DPEFVFYDQL KQVMNAYRVK PAIFDLLLAL CIGAYLGMAY 540 TAVQHFHVLY KTVQRLLLKA KAQ 563 |
Gene Ontology | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005634; C:nucleus; IEA:Compara. GO:0008233; F:peptidase activity; IEA:InterPro. GO:0006508; P:proteolysis; IEA:InterPro. GO:0009966; P:regulation of signal transduction; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |