CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039523
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 3-hydroxy-3-methylglutaryl-coenzyme A reductase 
Protein Synonyms/Alias
  
Gene Name
 Hmgcr 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
248VLEEEENKPNPVTQRubiquitination[1]
381LLVRRNQKLSSVEEDubiquitination[1]
459ENAEKGAKFLSDAEIubiquitination[1]
473IIQLVNAKHIPAYKLubiquitination[1]
479AKHIPAYKLETLMETubiquitination[1]
501RRQLLSTKLAEPSSLubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 819 AA 
Protein Sequence
MLSRLFRMHG LFVASHPWEV IVGTVTLTIC MMSMNMFTGN NKICGWNYEC PKFEEDVLSS 60
DIIILTITRC IAILYIYFQF QNLRQLGSKY ILGIAGLFTI FSSFVFSTVV IHFLDKELTG 120
LNEALPFFLL LIDLSRASAL AKFALSSNSQ DEVRENIARG MAILGPTFTL DALVECLVIG 180
VGTMSGVRQL EIMCCFGCMS VLANYFVFMT FFPACVSLVL ELSRESREGR PIWQLSHFAR 240
VLEEEENKPN PVTQRVKMIM SLGLVLVHAH SRWIADPSPQ NSTAEQAKVS LGLDEDVSKR 300
IEPSVSLWQF YLSKMISMDI EQVITLSLAF LLAVKYIFFE QAETESTLSL KNPITSPVVT 360
SKKAQDNCCR REPLLVRRNQ KLSSVEEDPG ANQERKVEVI KPLVVEAETT SRATFVLGAS 420
VASPPSALGT QEPGIELPIE PRPNEECLQI LENAEKGAKF LSDAEIIQLV NAKHIPAYKL 480
ETLMETHERG VSIRRQLLST KLAEPSSLQY LPYRDYNYSL VMGACCENVI GYMPIPVGVA 540
GPLCLDGKEY QVPMATTEGC LVASTNRGCR AISLGGGASS RVLADGMTRG PVVRLPRACD 600
SAEVKTWLET PEGFAVIKEA FDSTSRFARL QKLHVTMAGR NLYIRFQSRT GDAMGMNMIS 660
KGTEKALLKL QEFFPDMQIL AVSGNYCTDK KPAAINWIEG RGKTVVCEAV IPAKVVREVL 720
KTTTEAMVDV NINKNLVGSA MAGSIGGYNA HAANIVTAIY IACGQDAAQN VGSSNCITLM 780
EASGPTNEDL YISCTMPSIE IGTVGGGTNL LPQQACLQV 819 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; IEA:InterPro.
 GO:0016021; C:integral to membrane; IEA:InterPro.
 GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IDA:MGI.
 GO:0050661; F:NADP binding; IEA:InterPro.
 GO:0006695; P:cholesterol biosynthetic process; IDA:MGI.
 GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.
 GO:0009790; P:embryo development; IMP:MGI.
 GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
 GO:0043407; P:negative regulation of MAP kinase activity; IGI:MGI.
 GO:0008542; P:visual learning; IGI:MGI. 
Interpro
 IPR002202; HMG_CoA_Rdtase.
 IPR023074; HMG_CoA_Rdtase_cat.
 IPR023076; HMG_CoA_Rdtase_CS.
 IPR004554; HMG_CoA_Rdtase_eu_arc.
 IPR004816; HMG_CoA_Rdtase_metazoan.
 IPR023282; HMG_CoA_Rdtase_N.
 IPR009023; HMG_CoA_Rdtase_NAD(P)-bd.
 IPR009029; HMG_CoA_Rdtase_sub-bd.
 IPR000731; SSD. 
Pfam
 PF00368; HMG-CoA_red 
SMART
  
PROSITE
 PS00066; HMG_COA_REDUCTASE_1
 PS00318; HMG_COA_REDUCTASE_2
 PS50065; HMG_COA_REDUCTASE_4
 PS50156; SSD 
PRINTS
 PR00071; HMGCOARDTASE.