UniProt Accession

 RBMX_MOUSE; Q9WV02; Q8C2U6; Q9R0Y0 

Genbank Protein ID

 AJ237846; AJ237847; AK087940; AK135164; AK165006; AL672106; CH466583; CH466583; BC003710 

Genbank Nucleotide ID

 CAB51361.1; CAB51362.1; BAC40051.1; BAE22448.1; BAE37998.1; CAM22440.1; EDL42174.1; EDL42172.1; AAH03710.1 

Protein Name

 RNA-binding motif protein, X chromosome 

Protein Synonyms/Alias

 Heterogeneous nuclear ribonucleoprotein G; hnRNP G; RNA-binding motif protein, X chromosome, N-terminally processed 

Gene Name

 Rbmx 

Gene Synonyms/Alias

 Hnrnpg; Hnrpg; Rbmxp1; Rbmxrt 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
9	VEADRPGKLFIGGLN	ubiquitination	[1]
22	LNTETNEKALEAVFG	ubiquitination	[1]
30	ALEAVFGKYGRIVEV	ubiquitination	[1]
217	RDDGYSTKDSYSSRE	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single- stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Plays also a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1- beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment. 

Sequence Annotation

 DOMAIN 8 86 RRM.
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 2 2 N-acetylvaline; in RNA-binding motif
 MOD_RES 30 30 N6-acetyllysine (By similarity).
 MOD_RES 88 88 Phosphoserine (By similarity).
 MOD_RES 168 168 Phosphoserine.
 MOD_RES 185 185 Omega-N-methylated arginine (By
 MOD_RES 208 208 Phosphoserine.
 MOD_RES 329 329 Phosphoserine (By similarity).
 MOD_RES 332 332 Phosphoserine (By similarity).
 MOD_RES 352 352 Phosphoserine (By similarity).  

Keyword

 Acetylation; Activator; Alternative splicing; Complete proteome; Glycoprotein; Methylation; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Repressor; Ribonucleoprotein; RNA-binding; Spliceosome; Transcription; Tumor suppressor. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 391 AA 

Protein Sequence

Gene Ontology

 GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR012677; Nucleotide-bd_a/b_plait.
 IPR012604; RBM1CTR.
 IPR000504; RRM_dom. 

Pfam

 PF08081; RBM1CTR
 PF00076; RRM_1 

SMART

 SM00360; RRM 

PROSITE

 PS50102; RRM 

PRINTS