| Tag | Content |
|---|
| CPLM ID | CPLM-008273 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Tumor necrosis factor receptor superfamily member 3 |
Protein Synonyms/Alias | Lymphotoxin-beta receptor |
Gene Name | Ltbr |
Gene Synonyms/Alias | Tnfcr; Tnfrsf3 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 253 | RHPSLCRKLGTLLKR | acetylation | [1] |
|
Reference | [1] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW. Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [ PMID: 23576753] |
Functional Description | Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs (By similarity). |
Sequence Annotation | REPEAT 42 81 TNFR-Cys 1.
REPEAT 82 124 TNFR-Cys 2.
REPEAT 125 170 TNFR-Cys 3.
REPEAT 171 213 TNFR-Cys 4.
MOD_RES 315 315 Phosphoserine (By similarity).
CARBOHYD 40 40 N-linked (GlcNAc...) (Potential).
CARBOHYD 179 179 N-linked (GlcNAc...) (Potential).
DISULFID 43 58 By similarity.
DISULFID 59 72 By similarity.
DISULFID 62 80 By similarity.
DISULFID 83 98 By similarity.
DISULFID 101 116 By similarity.
DISULFID 104 124 By similarity.
DISULFID 126 132 By similarity.
DISULFID 139 150 By similarity.
DISULFID 142 169 By similarity.
DISULFID 172 187 By similarity. |
Keyword | Apoptosis; Complete proteome; Disulfide bond; Glycoprotein; Membrane; Phosphoprotein; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 415 AA |
Protein Sequence | MRLPRASSPC GLAWGPLLLG LSGLLVASQP QLVPPYRIEN QTCWDQDKEY YEPMHDVCCS 60
RCPPGEFVFA VCSRSQDTVC KTCPHNSYNE HWNHLSTCQL CRPCDIVLGF EEVAPCTSDR 120
KAECRCQPGM SCVYLDNECV HCEEERLVLC QPGTEAEVTD EIMDTDVNCV PCKPGHFQNT 180
SSPRARCQPH TRCEIQGLVE AAPGTSYSDT ICKNPPEPGA MLLLAILLSL VLFLLFTTVL 240
ACAWMRHPSL CRKLGTLLKR HPEGEESPPC PAPRADPHFP DLAEPLLPMS GDLSPSPAGP 300
PTAPSLEEVV LQQQSPLVQA RELEAEPGEH GQVAHGANGI HVTGGSVTVT GNIYIYNGPV 360
LGGTRGPGDP PAPPEPPYPT PEEGAPGPSE LSTPYQEDGK AWHLAETETL GCQDL 415 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. GO:0071260; P:cellular response to mechanical stimulus; IEA:Compara. GO:0048535; P:lymph node development; TAS:MGI. GO:2001238; P:positive regulation of extrinsic apoptotic signaling pathway; IEA:Compara. GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IEA:Compara. GO:0046330; P:positive regulation of JNK cascade; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |