UniProt Accession

 B1ATY9_MOUSE; B1ATY9 

Genbank Protein ID

 AL669855 

Genbank Nucleotide ID

  

Protein Name

 Hepatocyte growth factor-regulated tyrosine kinase substrate 

Protein Synonyms/Alias

  

Gene Name

 Hgs 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
43	RQGDTQAKYAVNSIK	acetylation	[1]
86	VHDEVANKQTMEELK	ubiquitination	[2]
93	KQTMEELKELLKAWA	ubiquitination	[2]
110	FRNEPKYKVVQDTYQ	ubiquitination	[2]
130	GHVFPEFKESDAMFA	ubiquitination	[2]
186	SKYSTIPKFGIEKEV	acetylation	[3]
205	PCYEQLNKKAEGKAS	ubiquitination	[2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Metal-binding; Reference proteome; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 245 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0016197; P:endosomal transport; IEA:InterPro.
 GO:0006886; P:intracellular protein transport; IEA:InterPro.
 GO:0009966; P:regulation of signal transduction; IEA:InterPro. 

Interpro

 IPR008942; ENTH_VHS.
 IPR027426; HGS.
 IPR002014; VHS.
 IPR018205; VHS_subgr.
 IPR000306; Znf_FYVE.
 IPR017455; Znf_FYVE-rel.
 IPR011011; Znf_FYVE_PHD.
 IPR013083; Znf_RING/FYVE/PHD. 

Pfam

 PF01363; FYVE
 PF00790; VHS 

SMART

 SM00064; FYVE
 SM00288; VHS 

PROSITE

 PS50179; VHS
 PS50178; ZF_FYVE 

PRINTS