UniProt Accession

 LIME1_HUMAN; Q9H400; E1P5K5; E1P5K6; Q5JWJ2; Q6XYB3; Q9NX69 

Genbank Protein ID

 AY203957; AK000413; AL121845; AL121845; CH471077; CH471077; CH471077; CH471077; CH471077; CH471077; BC017016 

Genbank Nucleotide ID

 AAP34480.1; BAA91148.1; CAC03671.1; CAI21882.1; EAW75213.1; EAW75214.1; EAW75215.1; EAW75216.1; EAW75217.1; EAW75218.1; AAH17016.1 

Protein Name

 Lck-interacting transmembrane adapter 1 

Protein Synonyms/Alias

 Lck-interacting membrane protein; Lck-interacting molecule 

Gene Name

 LIME1 

Gene Synonyms/Alias

 LIME; LP8067 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
73	THLCSLSKSDTRLHE	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T- cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4-mediated inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules. 

Sequence Annotation

 REGION 145 148 Interaction with GRB2 (By similarity).
 REGION 167 170 Interaction with CSK.
 REGION 200 203 Interaction with CSK.
 REGION 235 238 Interaction with LCK and PIK3R1 (By
 REGION 254 257 Interaction with LCK, PLCG2 and PIK3R1
 MOD_RES 167 167 Phosphotyrosine (Probable).
 MOD_RES 200 200 Phosphotyrosine.
 MOD_RES 254 254 Phosphotyrosine; by LCK (Probable).
 LIPID 28 28 S-palmitoyl cysteine (Probable).
 LIPID 31 31 S-palmitoyl cysteine (Probable).  

Keyword

 Adaptive immunity; Alternative splicing; Cell membrane; Complete proteome; Immunity; Lipoprotein; Membrane; Palmitate; Phosphoprotein; Polymorphism; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 295 AA 

Protein Sequence

Gene Ontology

 GO:0019815; C:B cell receptor complex; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0050853; P:B cell receptor signaling pathway; IEA:Compara.
 GO:0043405; P:regulation of MAP kinase activity; IEA:Compara.
 GO:0042345; P:regulation of NF-kappaB import into nucleus; IEA:Compara.
 GO:0014066; P:regulation of phosphatidylinositol 3-kinase cascade; IEA:Compara.
 GO:0051279; P:regulation of release of sequestered calcium ion into cytosol; IEA:Compara.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0050852; P:T cell receptor signaling pathway; IEA:InterPro. 

Interpro

 IPR026072; Lime1. 

Pfam

  

SMART

  

PROSITE

  

PRINTS