| Tag | Content |
|---|
| CPLM ID | CPLM-017160 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Melanin-concentrating hormone receptor 1 |
Protein Synonyms/Alias | MCH receptor 1; MCH-R1; MCHR-1; G-protein coupled receptor 24; MCH-1R; MCH1R; MCHR; SLC-1; Somatostatin receptor-like protein |
Gene Name | Mchr1 |
Gene Synonyms/Alias | Gpr24; Slc1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 397 | KRLVLSVKPAAQGQL | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis. |
Sequence Annotation | CARBOHYD 83 83 N-linked (GlcNAc...) (Potential).
CARBOHYD 86 86 N-linked (GlcNAc...) (Potential).
CARBOHYD 93 93 N-linked (GlcNAc...) (Potential). |
Keyword | Cell membrane; Complete proteome; G-protein coupled receptor; Glycoprotein; Membrane; Receptor; Reference proteome; Transducer; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 423 AA |
Protein Sequence | MSVGAGKEGV GRAVGLRGSR GCQAVEEDPF LDCGAQAPGQ GGGGRWRLPQ PAWVDGRALH 60
SREQATCTGC MDLQASLLST GPNASNISDG QDNFTLAGPP PRTRSVSYIN IIMPSVFGTI 120
CLLGIVGNST VIFAVVKKSK LHWCSNVPDI FIINLSVVDL LFLLGMPFMI HQLMGNGVWH 180
FGETMCTLIT AMDANSQFTS TYILTAMAID RYLATVHPIS STKFRKPSMA TLVICLLWAL 240
SFISITPVWL YARLIPFPGG AVGCGIRLPN PDTDLYWFTL YQFFLAFALP FVVITAAYVK 300
ILQRMTSSVA PASQRSIRLR TKRVTRTAIA ICLVFFVCWA PYYVLQLTQL SISRPTLTFV 360
YLYNAAISLG YANSCLNPFV YIVLCETFRK RLVLSVKPAA QGQLRTVSNA QTADEERTES 420
KGT 423 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0031513; C:nonmotile primary cilium; IDA:BHF-UCL. GO:0005886; C:plasma membrane; IDA:MGI. GO:0042562; F:hormone binding; IEA:Compara. GO:0030273; F:melanin-concentrating hormone receptor activity; IEA:InterPro. GO:0007204; P:elevation of cytosolic calcium ion concentration; IEA:Compara. GO:0007218; P:neuropeptide signaling pathway; IEA:InterPro. GO:0051928; P:positive regulation of calcium ion transport; IEA:Compara. GO:0060259; P:regulation of feeding behavior; TAS:BHF-UCL. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |